Functional and morphological development of the womb throughout life

Rachel E. Sheldon; Anatoly Shmygol; Hugo A. van den Berg; Andrew M. Blanks

doi:10.3184/003685015X14308363103415

Functional and morphological development of the womb throughout life

Rachel E. Sheldon, Anatoly Shmygol, Hugo A. van den Berg, Andrew M. Blanks

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The uterus undergoes changes throughout a woman’s life, beginning with her own embryonic development when she is still in the womb, commencing a monthly cycle at the onset of adulthood, and undergoing dramatic changes during pregnancy and parturition. The impact of preterm labour and other perinatal health problems is significant, both in human and financial terms; therefore the study of the physiological and regulatory changes which the uterus undergoes can be of enormous potential benefit. Here we briefly review the current state of knowledge, with an emphasis on the importance of changes in connectivity in the uterine smooth muscle cell network and on recent mathematical modelling work aimed at elucidating the role of spatial heterogeneity in this connected network.

Original language	English
Pages (from-to)	103-127
Number of pages	25
Journal	Science Progress
Volume	98
Issue number	2
DOIs	https://doi.org/10.3184/003685015X14308363103415
Publication status	Published - Jun 1 2015
Externally published	Yes

Keywords

Development
Electrophysiology
Mathematical model
Myometriocyte
Network theory
Parturition
Pregnancy
Smooth muscle
Uterus

ASJC Scopus subject areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3184/003685015X14308363103415

Cite this

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abstract = "The uterus undergoes changes throughout a woman{\textquoteright}s life, beginning with her own embryonic development when she is still in the womb, commencing a monthly cycle at the onset of adulthood, and undergoing dramatic changes during pregnancy and parturition. The impact of preterm labour and other perinatal health problems is significant, both in human and financial terms; therefore the study of the physiological and regulatory changes which the uterus undergoes can be of enormous potential benefit. Here we briefly review the current state of knowledge, with an emphasis on the importance of changes in connectivity in the uterine smooth muscle cell network and on recent mathematical modelling work aimed at elucidating the role of spatial heterogeneity in this connected network.",

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AU - Sheldon, Rachel E.

AU - Shmygol, Anatoly

AU - van den Berg, Hugo A.

AU - Blanks, Andrew M.

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KW - Electrophysiology

KW - Mathematical model

KW - Myometriocyte

KW - Network theory

KW - Parturition

KW - Pregnancy

KW - Smooth muscle

KW - Uterus

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Functional and morphological development of the womb throughout life

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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