Functional architecture of the SR calcium store in uterine smooth muscle

Anatoly Shmygol, Susan Wray

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Sarcoplasmic reticulum (SR) is abundant in uterine smooth muscle cells. The functional role of this organelle in the regulation of uterine myocytes is not fully understood. The data available in the literature suggest that SR plays a dual role: as a source of calcium and as a calcium sink shaping calcium transients produced by membrane depolarisation and uterotonic agonists. Advances in digital imaging techniques including confocal microscopy of isolated living cells, and the development of methods for direct measurement of intraluminal calcium, has triggered a substantial increase in the number of publications elucidating the role of intracellular stores in calcium signalling. In this paper we review the literature and our own work on the SR calcium store in uterine smooth muscle cells.

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalCell Calcium
Issue number6
Publication statusPublished - Jun 2004
Externally publishedYes


  • Calcium
  • Sarcoplasmic reticulum
  • Smooth muscle cells

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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