Galactose inhibition of citric acid production from glucose by Aspergillus niger

M. Hossain, J. D. Brooks, I. S. Maddox

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13 Citations (Scopus)


Previous work in this laboratory has demonstrated that although Aspergillus niger can readily utilize galactose, no citric acid is produced from this carbon source (Hossain et al. 1984). Experiments were now conducted where galactose was added at various concentrations to synthetic growth medium containing glucose as carbon source, so that the effect of galactose on citric acid production from glucose could be observed. The results showed that the presence of galactose or a product of galactose metabolism caused inhibition of citric acid production, and also reduced the rate of glucose utilization. Enzyme analyses using mycelial cell-free extracts indicated that galactose interfered with the glucose-repression of the key enzyme 2-oxoglutarate dehydrogenase.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalApplied Microbiology and Biotechnology
Issue number2
Publication statusPublished - Jun 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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