Abstract
Background: Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease, caused by a deficiency of arylsulfatase A, and leads to demyelination of the nervous system. A putative association between MLD and gallbladder pathology including malignancy is documented in the medical literature. Case report: A 10-year-old boy with MLD was found to have a papillary growth within a cystically dilated gallbladder. The lesion was confirmed to be papillomatosis/polyp with focal intestinal metaplasia. Dysplasia was not identified. Conclusion: MLD may be associated with a spectrum of gallbladder pathology including neoplastic conditions. Pathologists and clinicians should be aware of this association/risk. The patient may be offered regular ultrasound screening of the gallbladder.
Original language | English |
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Pages (from-to) | 102-108 |
Number of pages | 7 |
Journal | Fetal and Pediatric Pathology |
Volume | 37 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 4 2018 |
Keywords
- gallbladder papillomatosis
- metachromatic leukodystrophy
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pathology and Forensic Medicine