TY - JOUR
T1 - Garlic bioactive substances and their therapeutic applications for improving human health
T2 - a comprehensive review
AU - El-Saadony, Mohamed T.
AU - Saad, Ahmed M.
AU - Korma, Sameh A.
AU - Salem, Heba M.
AU - Abd El-Mageed, Taia A.
AU - Alkafaas, Samar Sami
AU - Elsalahaty, Mohamed I.
AU - Elkafas, Sara Samy
AU - Mosa, Walid F.A.
AU - Ahmed, Ahmed Ezzat
AU - Mathew, Betty T.
AU - Albastaki, Noor A.
AU - Alkuwaiti, Aysha A.
AU - El-Tarabily, Marawan K.
AU - AbuQamar, Synan F.
AU - El-Tarabily, Khaled A.
AU - Ibrahim, Salam A.
N1 - Publisher Copyright:
Copyright © 2024 El-Saadony, Saad, Korma, Salem, Abd El-Mageed, Alkafaas, Elsalahaty, Elkafas, Mosa, Ahmed, Mathew, Albastaki, Alkuwaiti, El-Tarabily, AbuQamar, El-Tarabily and Ibrahim.
PY - 2024
Y1 - 2024
N2 - Garlic (Allium sativum L.) is a widely abundant spice, known for its aroma and pungent flavor. It contains several bioactive compounds and offers a wide range of health benefits to humans, including those pertaining to nutrition, physiology, and medicine. Therefore, garlic is considered as one of the most effective disease-preventive diets. Many in vitro and in vivo studies have reported the sulfur-containing compounds, allicin and ajoene, for their effective anticancer, anti-diabetic, anti-inflammatory, antioxidant, antimicrobial, immune-boosting, and cardioprotective properties. As a rich natural source of bioactive compounds, including polysaccharides, saponins, tannins, linalool, geraniol, phellandrene, β-phellandrene, ajoene, alliin, S-allyl-mercapto cysteine, and β-phellandrene, garlic has many therapeutic applications and may play a role in drug development against various human diseases. In the current review, garlic and its major bioactive components along with their biological function and mechanisms of action for their role in disease prevention and therapy are discussed.
AB - Garlic (Allium sativum L.) is a widely abundant spice, known for its aroma and pungent flavor. It contains several bioactive compounds and offers a wide range of health benefits to humans, including those pertaining to nutrition, physiology, and medicine. Therefore, garlic is considered as one of the most effective disease-preventive diets. Many in vitro and in vivo studies have reported the sulfur-containing compounds, allicin and ajoene, for their effective anticancer, anti-diabetic, anti-inflammatory, antioxidant, antimicrobial, immune-boosting, and cardioprotective properties. As a rich natural source of bioactive compounds, including polysaccharides, saponins, tannins, linalool, geraniol, phellandrene, β-phellandrene, ajoene, alliin, S-allyl-mercapto cysteine, and β-phellandrene, garlic has many therapeutic applications and may play a role in drug development against various human diseases. In the current review, garlic and its major bioactive components along with their biological function and mechanisms of action for their role in disease prevention and therapy are discussed.
KW - Allium sativum
KW - bioactive compounds
KW - functional foods
KW - human diseases
KW - human health
KW - mechanisms of action
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=85196662938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85196662938&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2024.1277074
DO - 10.3389/fimmu.2024.1277074
M3 - Review article
C2 - 38915405
AN - SCOPUS:85196662938
SN - 1664-3224
VL - 15
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 1277074
ER -
