TY - JOUR
T1 - Gastric acid blockade with omeprazole promotes gastric carcinogenesis induced by duodenogastric reflux
AU - Wetscher, Gerold J.
AU - Hinder, Ronald A.
AU - Smyrk, Tom
AU - Perdikis, Galen
AU - Adrian, Thomas E.
AU - Profanter, Christoph
PY - 1999
Y1 - 1999
N2 - Duodenogastric reflux (DGR) in rats causes growth stimulation of the foregut mucosa that is potentiated by gastric acid blockade. It was the aim of this study to investigate if DGR with gastric acid blockade has a higher incidence of carcinomas of the foregut than DGR alone. DGR was induced in 40 Sprague-Dawley rats using a split gastroenterostomy. A cardiomyotomy was performed across the gastroesophageal junction, inducing reflux into the esophagus. Twenty of these rats received omeprazole postoperatively. After one year 18 rats (90%) with DGR + omeprazole treatment and 7 rats (35%) with DGR alone developed adenocarcinoma of the stomach (P < 0.05). None of the rats developed esophageal cancer, but esophageal mucosal hyperplasia was more pronounced in rats receiving omeprazole. Control rats, treated with omeprazole, did not develop carcinomas of the foregut. In conclusion, gastric acid blockade enhanced DGR-induced carcinogenesis of the stomach and promotes growth stimulation of the esophageal mucosa.
AB - Duodenogastric reflux (DGR) in rats causes growth stimulation of the foregut mucosa that is potentiated by gastric acid blockade. It was the aim of this study to investigate if DGR with gastric acid blockade has a higher incidence of carcinomas of the foregut than DGR alone. DGR was induced in 40 Sprague-Dawley rats using a split gastroenterostomy. A cardiomyotomy was performed across the gastroesophageal junction, inducing reflux into the esophagus. Twenty of these rats received omeprazole postoperatively. After one year 18 rats (90%) with DGR + omeprazole treatment and 7 rats (35%) with DGR alone developed adenocarcinoma of the stomach (P < 0.05). None of the rats developed esophageal cancer, but esophageal mucosal hyperplasia was more pronounced in rats receiving omeprazole. Control rats, treated with omeprazole, did not develop carcinomas of the foregut. In conclusion, gastric acid blockade enhanced DGR-induced carcinogenesis of the stomach and promotes growth stimulation of the esophageal mucosa.
KW - Carcinogenesis
KW - Duodenogastric reflux
KW - Esophagus
KW - Stomach
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U2 - 10.1023/A:1026615905170
DO - 10.1023/A:1026615905170
M3 - Article
C2 - 10389684
AN - SCOPUS:0033031754
SN - 0002-9211
VL - 44
SP - 1132
EP - 1135
JO - American Journal of Digestive Diseases
JF - American Journal of Digestive Diseases
IS - 6
ER -