Gastroduodenal mucosal hormone content in duodenal ulcer disease

S. Domschke, S. R. Bloom, T. E. Adrian, G. Lux, M. G. Bryant

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To further elucidate the pathophysiological role of peptide hormones in duodenal ulcer (DU) disease, several endocrine, paracrine and neurocrine peptides were determined radioimmunologically in biopsies of gastroduodenal mucosa obtained endoscopically in 8 subjects without upper gastrointestinal disease, and in 8 duodenal ulcer patients. The DU patients had a BAO of 6.6 ± 1.9 and a PAO of 41.8 ± 6.1 mEq/h. In DU patients, a lack of the acid and gastrin-release inhibiting agent somatostatin was found neither in antral nor in fundic mucosa (185 ± 60 vs 83 ± 19 pmol/g tissue wet weight in controls). Basal and peak acid outputs of DU patients were positively correlated with fundic somatostatin concentrations (p < 0.01). While gastrin levels were not significantly elevated in the antrum of DU patients, the mucosal content of potentially releasable gastrin of the duodenal bulb and the descending duodenum was higher than in controls (p < 0.01). In the whole duodenum, CCK-like immunoreactivity was also more abundant in DU patients than in controls, whereas GIP and motilin did not exhibit characteristic profiles. Presumably as a reactive phenomenon, the mucosal levels of the peptidergic neurotransmitters VIP and substance P were markedly increased in the proximal duodenum of DU patients.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalHepato-Gastroenterology
Volume32
Issue number4
Publication statusPublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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