Gene-disease association through topological and biological feature integration

Eileen Marie Hanna, Nazar M. Zaki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The large amounts of biological information generated using advanced high-throughput experimental techniques continue to motivate the design of suitable methods for valuable knowledge mining. Finding proper means to examine and analyze such information allows better understanding of normal biological processes as well as uncovering malfunctions that trigger various diseases. Several computational approaches were developed to complement the experimental work which is often restricted by high time and cost requirements. In this paper, we consider the problem of disease- gene association and we propose a methodology based on a classification approach which integrates protein-protein interaction network topology features and biological information collected from various data sources. When applied on a dataset of multiple disease types and using the Naive Bayes classifier, our method achieves an AUC score of 0.941. We also consider two case studies of type II diabetes mellitus and breast cancer. The experimental results greatly favor our approach.

Original languageEnglish
Title of host publicationProceedings - 2015 11th International Conference on Innovations in Information Technology, IIT 2015
EditorsLeila Ismail
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages225-229
Number of pages5
ISBN (Electronic)9781467385114
DOIs
Publication statusPublished - Jan 12 2016
Event11th International Conference on Innovations in Information Technology, IIT 2015 - Dubai, United Arab Emirates
Duration: Nov 1 2015Nov 3 2015

Publication series

NameProceedings - 2015 11th International Conference on Innovations in Information Technology, IIT 2015

Other

Other11th International Conference on Innovations in Information Technology, IIT 2015
Country/TerritoryUnited Arab Emirates
CityDubai
Period11/1/1511/3/15

Keywords

  • biological features
  • gene-disease association
  • protein-protein interactions
  • topological features

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications
  • Communication

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