Gene subset selection using an iterative approach based on genetic algorithms

M. S. Mohamad, S. Omatu, S. Deris, M. Yoshioka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microarray data are expected to be useful for cancer classification. The main problem that needs to be addressed is the selection of a smaller subset of genes from the thousands of genes in the data that contributes to a disease. This selection process is difficult due to many irrelevant genes, noisy genes, and the availability of a small number of samples compared to a huge number of genes (higher-dimensional data). Hence, this paper aims to select a near-optimal (smaller) subset of informative genes that is most relevant for the cancer classification. To achieve the aim, an iterative approach based on genetic algorithms has been proposed. Experimental results show that the performance of the proposed approach is superior to other related previous works as well as four methods experimented in this work. In addition a list of informative genes in the best gene subsets is also presented for biological usage.

Original languageEnglish
Title of host publicationProceedings of the 14th International Symposium on Artificial Life and Robotics, AROB 14th'09
Pages758-761
Number of pages4
Publication statusPublished - 2009
Externally publishedYes
Event14th International Symposium on Artificial Life and Robotics, AROB 14th'09 - Oita, Japan
Duration: Feb 5 2008Feb 7 2009

Publication series

NameProceedings of the 14th International Symposium on Artificial Life and Robotics, AROB 14th'09

Conference

Conference14th International Symposium on Artificial Life and Robotics, AROB 14th'09
Country/TerritoryJapan
CityOita
Period2/5/082/7/09

Keywords

  • Gene selection
  • Genetic algorithm
  • Iterative approach
  • Microarray data

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Vision and Pattern Recognition
  • Human-Computer Interaction

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