TY - JOUR
T1 - Genetic analysis of the gene for porcine submaxillary gland mucin
T2 - Physical assignment of the MUC and interferon γ genes to chromosome 5
AU - Johansson, M.
AU - Chowdhary, B.
AU - Gu, F.
AU - Ellegren, H.
AU - Gustavsson, I.
AU - Andersson, L.
N1 - Funding Information:
From the Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7055, S-75007 Uppsala, Sweden. We thank Ulla Gus-tavsson and Lena Marklund for excellent technical assistance and Dr. R. L. Hill and Dr. C. R. Maliszewski for kindly providing the probes for porcine mucin and bovine interferon y genes, respectively. The work is associated with the ongoing European pig gene mapping project (PiGMaP) and is financially supported by the Nordic Council of Ministers.
PY - 1993
Y1 - 1993
N2 - Genetic variation at the porcine submaxillary gland mucin (MUC) locus was revealed by RFLP analysis. A three-allele system was defined, and codominant inheritance was confirmed using a three-generation pedigree comprising 10 founder individuals, 26 F1 animals, and 200 F2 offspring. Linkage analysis was performed against a set of 56 genetic markers. The mucin locus was assigned to a previously reported linkage group comprising the markers interferon γ (IFNG), diacylglycerol kinase (DAGK), and an anonymous microsatellite (S0092). Furthermore, the genes for mucin and interferon γ were physically localized to porcine chromosome 5q2.3 and 5p1.2-q1.1 by fluorescence and radioactive in situ hybridization, respectively, thereby assigning four new markers to chromosome 5. This chromosome shares homologies with chromosome 5 in cattle and chromosome 12 in humans.
AB - Genetic variation at the porcine submaxillary gland mucin (MUC) locus was revealed by RFLP analysis. A three-allele system was defined, and codominant inheritance was confirmed using a three-generation pedigree comprising 10 founder individuals, 26 F1 animals, and 200 F2 offspring. Linkage analysis was performed against a set of 56 genetic markers. The mucin locus was assigned to a previously reported linkage group comprising the markers interferon γ (IFNG), diacylglycerol kinase (DAGK), and an anonymous microsatellite (S0092). Furthermore, the genes for mucin and interferon γ were physically localized to porcine chromosome 5q2.3 and 5p1.2-q1.1 by fluorescence and radioactive in situ hybridization, respectively, thereby assigning four new markers to chromosome 5. This chromosome shares homologies with chromosome 5 in cattle and chromosome 12 in humans.
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U2 - 10.1093/oxfordjournals.jhered.a111336
DO - 10.1093/oxfordjournals.jhered.a111336
M3 - Article
C2 - 8101856
AN - SCOPUS:0027254784
SN - 0022-1503
VL - 84
SP - 259
EP - 262
JO - Journal of Heredity
JF - Journal of Heredity
IS - 4
ER -