Genetic underpinnings in Alzheimer's disease - A review

Ahmed A. Moustafa; Mubashir Hassan; Doaa H. Hewedi; Iman Hewedi; Julia K. Garami; Hany Al Ashwal; Nazar Zaki; Sung Yum Seo; Vassilis Cutsuridis; Sergio L. Angulo; Joman Y. Natesh; Mohammad M. Herzallah; Dorota Frydecka; Błazej Misiak; Mohamed Salama; Wael Mohamed; Mohamad El Haj; Michael Hornberger

doi:10.1515/revneuro-2017-0036

Genetic underpinnings in Alzheimer's disease - A review

Ahmed A. Moustafa, Mubashir Hassan, Doaa H. Hewedi, Iman Hewedi, Julia K. Garami, Hany Al Ashwal, Nazar Zaki, Sung Yum Seo, Vassilis Cutsuridis, Sergio L. Angulo, Joman Y. Natesh, Mohammad M. Herzallah, Dorota Frydecka, Błazej Misiak, Mohamed Salama, Wael Mohamed, Mohamad El Haj, Michael Hornberger

Department of Computer Science and Software Engineering

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.

Original language	English
Pages (from-to)	21-38
Number of pages	18
Journal	Unknown Journal
Volume	29
Issue number	1
DOIs	https://doi.org/10.1515/revneuro-2017-0036
Publication status	Published - Dec 20 2017

Keywords

AChE
APP
Alzheimer's disease
BChE
amyloid-β
genetics
presenilin
prevalence vs. penetrance of genes

ASJC Scopus subject areas

General Neuroscience

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10.1515/revneuro-2017-0036

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Moustafa, A. A., Hassan, M., Hewedi, D. H., Hewedi, I., Garami, J. K., Al Ashwal, H., Zaki, N., Seo, S. Y., Cutsuridis, V., Angulo, S. L., Natesh, J. Y., Herzallah, M. M., Frydecka, D., Misiak, B., Salama, M., Mohamed, W., El Haj, M., & Hornberger, M. (2017). Genetic underpinnings in Alzheimer's disease - A review. Unknown Journal, 29(1), 21-38. https://doi.org/10.1515/revneuro-2017-0036

Moustafa, AA, Hassan, M, Hewedi, DH, Hewedi, I, Garami, JK, Al Ashwal, H , Zaki, N, Seo, SY, Cutsuridis, V, Angulo, SL, Natesh, JY, Herzallah, MM, Frydecka, D, Misiak, B, Salama, M, Mohamed, W, El Haj, M & Hornberger, M 2017, 'Genetic underpinnings in Alzheimer's disease - A review', Unknown Journal, vol. 29, no. 1, pp. 21-38. https://doi.org/10.1515/revneuro-2017-0036

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abstract = "In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.",

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author = "Moustafa, {Ahmed A.} and Mubashir Hassan and Hewedi, {Doaa H.} and Iman Hewedi and Garami, {Julia K.} and {Al Ashwal}, Hany and Nazar Zaki and Seo, {Sung Yum} and Vassilis Cutsuridis and Angulo, {Sergio L.} and Natesh, {Joman Y.} and Herzallah, {Mohammad M.} and Dorota Frydecka and B{\l}azej Misiak and Mohamed Salama and Wael Mohamed and {El Haj}, Mohamad and Michael Hornberger",

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AU - Garami, Julia K.

AU - Al Ashwal, Hany

AU - Zaki, Nazar

AU - Seo, Sung Yum

AU - Cutsuridis, Vassilis

AU - Angulo, Sergio L.

AU - Natesh, Joman Y.

AU - Herzallah, Mohammad M.

AU - Frydecka, Dorota

AU - Misiak, Błazej

AU - Salama, Mohamed

AU - Mohamed, Wael

AU - El Haj, Mohamad

AU - Hornberger, Michael

PY - 2017/12/20

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N2 - In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.

AB - In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations. Rigorous data mining approaches justified the significant role of genes in AD prevalence. Pedigree analysis and twin studies suggest that genetic components are part of the etiology, rather than only being risk factors for AD. The first autosomal dominant mutation in the amyloid precursor protein (APP) gene was described in 1991. Later, AD was also associated with mutated early-onset (presenilin 1/2, PSEN1/2 and APP) and late-onset (apolipoprotein E, ApoE) genes. Genome-wide association and linkage analysis studies with identified multiple genomic areas have implications for the treatment of AD. We conclude this review with future directions and clinical implications of genetic research in AD.

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Genetic underpinnings in Alzheimer's disease - A review

Abstract

Keywords

ASJC Scopus subject areas

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