Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Milind V. Masule; Sumit Rathod; Yogeeta Agrawal; Chandragouda R. Patil; Kartik T. Nakhate; Shreesh Ojha; Sameer N. Goyal; Umesh B. Mahajan

doi:10.1016/j.crphar.2022.100113

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Milind V. Masule, Sumit Rathod, Yogeeta Agrawal, Chandragouda R. Patil, Kartik T. Nakhate, Shreesh Ojha, Sameer N. Goyal, Umesh B. Mahajan

Department of Pharmacology and Therapeutics

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.

Original language	English
Article number	100113
Journal	Current Research in Pharmacology and Drug Discovery
Volume	3
DOIs	https://doi.org/10.1016/j.crphar.2022.100113
Publication status	Published - Jan 2022

Keywords

Depression
GHSR
Ghrelin
Neurotransmitter
Psychotic disorders

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Animal Science and Zoology

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10.1016/j.crphar.2022.100113

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title = "Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders",

abstract = "Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.",

keywords = "Depression, GHSR, Ghrelin, Neurotransmitter, Psychotic disorders",

author = "Masule, {Milind V.} and Sumit Rathod and Yogeeta Agrawal and Patil, {Chandragouda R.} and Nakhate, {Kartik T.} and Shreesh Ojha and Goyal, {Sameer N.} and Mahajan, {Umesh B.}",

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year = "2022",

month = jan,

doi = "10.1016/j.crphar.2022.100113",

language = "English",

volume = "3",

journal = "Current Research in Pharmacology and Drug Discovery",

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T1 - Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

AU - Masule, Milind V.

AU - Rathod, Sumit

AU - Agrawal, Yogeeta

AU - Patil, Chandragouda R.

AU - Nakhate, Kartik T.

AU - Ojha, Shreesh

AU - Goyal, Sameer N.

AU - Mahajan, Umesh B.

PY - 2022/1

Y1 - 2022/1

N2 - Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.

AB - Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.

KW - Depression

KW - GHSR

KW - Ghrelin

KW - Neurotransmitter

KW - Psychotic disorders

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U2 - 10.1016/j.crphar.2022.100113

DO - 10.1016/j.crphar.2022.100113

M3 - Review article

AN - SCOPUS:85132913833

SN - 2590-2571

VL - 3

JO - Current Research in Pharmacology and Drug Discovery

JF - Current Research in Pharmacology and Drug Discovery

M1 - 100113

ER -

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Abstract

Keywords

ASJC Scopus subject areas

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