Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)

Massimo Sartelli; Fikri M. Abu-Zidan; Fausto Catena; Ewen A. Griffiths; Salomone Di Saverio; Raul Coimbra; Carlos A. Ordoñez; Ari Leppaniemi; Gustavo P. Fraga; Federico Coccolini; Ferdinando Agresta; Asrhaf Abbas; Saleh Abdel Kader; John Agboola; Adamu Amhed; Adesina Ajibade; Seckin Akkucuk; Bandar Alharthi; Dimitrios Anyfantakis; Goran Augustin; Gianluca Baiocchi; Miklosh Bala; Oussama Baraket; Savas Bayrak; Giovanni Bellanova; Marcelo A. Beltràn; Roberto Bini; Matthew Boal; Andrey V. Borodach; Konstantinos Bouliaris; Frederic Branger; Daniele Brunelli; Marco Catani; Asri Che Jusoh; Alain Chichom-Mefire; Gianfranco Cocorullo; Elif Colak; David Costa; Silvia Costa; Yunfeng Cui; Geanina Loredana Curca; Terry Curry; Koray Das; Samir Delibegovic; Zaza Demetrashvili; Isidoro Di Carlo; Nadezda Drozdova; Tamer El Zalabany; Mushira Abdulaziz Enani; Mario Faro; Mahir Gachabayov; Teresa Giménez Maurel; Georgios Gkiokas; Carlos Augusto Gomes; Ricardo Alessandro Teixeira Gonsaga; Gianluca Guercioni; Ali Guner; Sanjay Gupta; Sandra Gutierrez; Martin Hutan; Orestis Ioannidis; Arda Isik; Yoshimitsu Izawa; Sumita A. Jain; Mantas Jokubauskas; Aleksandar Karamarkovic; Saila Kauhanen; Robin Kaushik; Jakub Kenig; Vladimir Khokha; Jae Il Kim; Victor Kong; Renol Koshy; Avidyl Krasniqi; Ashok Kshirsagar; Zygimantas Kuliesius; Konstantinos Lasithiotakis; Pedro Leão; Jae Gil Lee; Miguel Leon; Aintzane Lizarazu Pérez; Varut Lohsiriwat; Eudaldo López-Tomassetti Fernandez; Eftychios Lostoridis; Raghuveer Mn; Piotr Major; Athanasios Marinis; Daniele Marrelli; Aleix Martinez-Perez; Sanjay Marwah; Michael McFarlane; Renato Bessa Melo; Cristian Mesina; Nick Michalopoulos; Radu Moldovanu; Ouadii Mouaqit; Akutu Munyika; Ionut Negoi; Ioannis Nikolopoulos; Gabriela Elisa Nita; Iyiade Olaoye; Abdelkarim Omari; Paola Rodríguez Ossa; Zeynep Ozkan; Ramakrishnapillai Padmakumar; Francesco Pata; Gerson Alves Pereira Junior; Jorge Pereira; Tadeja Pintar; Konstantinos Pouggouras; Vinod Prabhu; Stefano Rausei; Miran Rems; Daniel Rios-Cruz; Boris Sakakushev; Maria Luisa Sánchez de Molina; Charampolos Seretis; Vishal Shelat; Romeo Lages Simões; Giovanni Sinibaldi; Matej Skrovina; Dmitry Smirnov; Charalampos Spyropoulos; Jaan Tepp; Tugan Tezcaner; Matti Tolonen; Myftar Torba; Jan Ulrych; Mustafa Yener Uzunoglu; David van Dellen; Gabrielle H. van Ramshorst; Giorgio Vasquez; Aurélien Venara; Andras Vereczkei; Nereo Vettoretto; Nutu Vlad; Sanjay Kumar Yadav; Tonguç Utku Yilmaz; Kuo Ching Yuan; Sanoop Koshy Zachariah; Maurice Zida; Justas Zilinskas; Luca Ansaloni

doi:10.1186/s13017-015-0055-0

Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)

Massimo Sartelli, Fikri M. Abu-Zidan, Fausto Catena, Ewen A. Griffiths, Salomone Di Saverio, Raul Coimbra, Carlos A. Ordoñez, Ari Leppaniemi, Gustavo P. Fraga, Federico Coccolini, Ferdinando Agresta, Asrhaf Abbas, Saleh Abdel Kader, John Agboola, Adamu Amhed, Adesina Ajibade, Seckin Akkucuk, Bandar Alharthi, Dimitrios Anyfantakis, Goran AugustinGianluca Baiocchi, Miklosh Bala, Oussama Baraket, Savas Bayrak, Giovanni Bellanova, Marcelo A. Beltràn, Roberto Bini, Matthew Boal, Andrey V. Borodach, Konstantinos Bouliaris, Frederic Branger, Daniele Brunelli, Marco Catani, Asri Che Jusoh, Alain Chichom-Mefire, Gianfranco Cocorullo, Elif Colak, David Costa, Silvia Costa, Yunfeng Cui, Geanina Loredana Curca, Terry Curry, Koray Das, Samir Delibegovic, Zaza Demetrashvili, Isidoro Di Carlo, Nadezda Drozdova, Tamer El Zalabany, Mushira Abdulaziz Enani, Mario Faro, Mahir Gachabayov, Teresa Giménez Maurel, Georgios Gkiokas, Carlos Augusto Gomes, Ricardo Alessandro Teixeira Gonsaga, Gianluca Guercioni, Ali Guner, Sanjay Gupta, Sandra Gutierrez, Martin Hutan, Orestis Ioannidis, Arda Isik, Yoshimitsu Izawa, Sumita A. Jain, Mantas Jokubauskas, Aleksandar Karamarkovic, Saila Kauhanen, Robin Kaushik, Jakub Kenig, Vladimir Khokha, Jae Il Kim, Victor Kong, Renol Koshy, Avidyl Krasniqi, Ashok Kshirsagar, Zygimantas Kuliesius, Konstantinos Lasithiotakis, Pedro Leão, Jae Gil Lee, Miguel Leon, Aintzane Lizarazu Pérez, Varut Lohsiriwat, Eudaldo López-Tomassetti Fernandez, Eftychios Lostoridis, Raghuveer Mn, Piotr Major, Athanasios Marinis, Daniele Marrelli, Aleix Martinez-Perez, Sanjay Marwah, Michael McFarlane, Renato Bessa Melo, Cristian Mesina, Nick Michalopoulos, Radu Moldovanu, Ouadii Mouaqit, Akutu Munyika, Ionut Negoi, Ioannis Nikolopoulos, Gabriela Elisa Nita, Iyiade Olaoye, Abdelkarim Omari, Paola Rodríguez Ossa, Zeynep Ozkan, Ramakrishnapillai Padmakumar, Francesco Pata, Gerson Alves Pereira Junior, Jorge Pereira, Tadeja Pintar, Konstantinos Pouggouras, Vinod Prabhu, Stefano Rausei, Miran Rems, Daniel Rios-Cruz, Boris Sakakushev, Maria Luisa Sánchez de Molina, Charampolos Seretis, Vishal Shelat, Romeo Lages Simões, Giovanni Sinibaldi, Matej Skrovina, Dmitry Smirnov, Charalampos Spyropoulos, Jaan Tepp, Tugan Tezcaner, Matti Tolonen, Myftar Torba, Jan Ulrych, Mustafa Yener Uzunoglu, David van Dellen, Gabrielle H. van Ramshorst, Giorgio Vasquez, Aurélien Venara, Andras Vereczkei, Nereo Vettoretto, Nutu Vlad, Sanjay Kumar Yadav, Tonguç Utku Yilmaz, Kuo Ching Yuan, Sanoop Koshy Zachariah, Maurice Zida, Justas Zilinskas, Luca Ansaloni

Department of Surgery

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.

Original language	English
Article number	61
Journal	World Journal of Emergency Surgery
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13017-015-0055-0
Publication status	Published - Dec 16 2015

Keywords

Infections
Intra-abdominal
Sepsis
Septic shock

ASJC Scopus subject areas

Surgery
Emergency Medicine

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10.1186/s13017-015-0055-0

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Sartelli, M., Abu-Zidan, F. M., Catena, F., Griffiths, E. A., Di Saverio, S., Coimbra, R., Ordoñez, C. A., Leppaniemi, A., Fraga, G. P., Coccolini, F., Agresta, F., Abbas, A., Abdel Kader, S., Agboola, J., Amhed, A., Ajibade, A., Akkucuk, S., Alharthi, B., Anyfantakis, D., ... Ansaloni, L. (2015). Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study). World Journal of Emergency Surgery, 10(1), Article 61. https://doi.org/10.1186/s13017-015-0055-0

Sartelli, M, Abu-Zidan, FM, Catena, F, Griffiths, EA, Di Saverio, S, Coimbra, R, Ordoñez, CA, Leppaniemi, A, Fraga, GP, Coccolini, F, Agresta, F, Abbas, A, Abdel Kader, S, Agboola, J, Amhed, A, Ajibade, A, Akkucuk, S, Alharthi, B, Anyfantakis, D, Augustin, G, Baiocchi, G, Bala, M, Baraket, O, Bayrak, S, Bellanova, G, Beltràn, MA, Bini, R, Boal, M, Borodach, AV, Bouliaris, K, Branger, F, Brunelli, D, Catani, M, Che Jusoh, A, Chichom-Mefire, A, Cocorullo, G, Colak, E, Costa, D, Costa, S, Cui, Y, Curca, GL, Curry, T, Das, K, Delibegovic, S, Demetrashvili, Z, Di Carlo, I, Drozdova, N, El Zalabany, T, Enani, MA, Faro, M, Gachabayov, M, Giménez Maurel, T, Gkiokas, G, Gomes, CA, Gonsaga, RAT, Guercioni, G, Guner, A, Gupta, S, Gutierrez, S, Hutan, M, Ioannidis, O, Isik, A, Izawa, Y, Jain, SA, Jokubauskas, M, Karamarkovic, A, Kauhanen, S, Kaushik, R, Kenig, J, Khokha, V, Kim, JI, Kong, V, Koshy, R, Krasniqi, A, Kshirsagar, A, Kuliesius, Z, Lasithiotakis, K, Leão, P, Lee, JG, Leon, M, Lizarazu Pérez, A, Lohsiriwat, V, López-Tomassetti Fernandez, E, Lostoridis, E, Mn, R, Major, P, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, McFarlane, M, Melo, RB, Mesina, C, Michalopoulos, N, Moldovanu, R, Mouaqit, O, Munyika, A, Negoi, I, Nikolopoulos, I, Nita, GE, Olaoye, I, Omari, A, Ossa, PR, Ozkan, Z, Padmakumar, R, Pata, F, Pereira Junior, GA, Pereira, J, Pintar, T, Pouggouras, K, Prabhu, V, Rausei, S, Rems, M, Rios-Cruz, D, Sakakushev, B, Sánchez de Molina, ML, Seretis, C, Shelat, V, Simões, RL, Sinibaldi, G, Skrovina, M, Smirnov, D, Spyropoulos, C, Tepp, J, Tezcaner, T, Tolonen, M, Torba, M, Ulrych, J, Uzunoglu, MY, van Dellen, D, van Ramshorst, GH, Vasquez, G, Venara, A, Vereczkei, A, Vettoretto, N, Vlad, N, Yadav, SK, Yilmaz, TU, Yuan, KC, Zachariah, SK, Zida, M, Zilinskas, J & Ansaloni, L 2015, 'Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)', World Journal of Emergency Surgery, vol. 10, no. 1, 61. https://doi.org/10.1186/s13017-015-0055-0

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title = "Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)",

abstract = "Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.",

keywords = "Infections, Intra-abdominal, Sepsis, Septic shock",

author = "Massimo Sartelli and Abu-Zidan, {Fikri M.} and Fausto Catena and Griffiths, {Ewen A.} and {Di Saverio}, Salomone and Raul Coimbra and Ordo{\~n}ez, {Carlos A.} and Ari Leppaniemi and Fraga, {Gustavo P.} and Federico Coccolini and Ferdinando Agresta and Asrhaf Abbas and {Abdel Kader}, Saleh and John Agboola and Adamu Amhed and Adesina Ajibade and Seckin Akkucuk and Bandar Alharthi and Dimitrios Anyfantakis and Goran Augustin and Gianluca Baiocchi and Miklosh Bala and Oussama Baraket and Savas Bayrak and Giovanni Bellanova and Beltr{\`a}n, {Marcelo A.} and Roberto Bini and Matthew Boal and Borodach, {Andrey V.} and Konstantinos Bouliaris and Frederic Branger and Daniele Brunelli and Marco Catani and {Che Jusoh}, Asri and Alain Chichom-Mefire and Gianfranco Cocorullo and Elif Colak and David Costa and Silvia Costa and Yunfeng Cui and Curca, {Geanina Loredana} and Terry Curry and Koray Das and Samir Delibegovic and Zaza Demetrashvili and {Di Carlo}, Isidoro and Nadezda Drozdova and {El Zalabany}, Tamer and Enani, {Mushira Abdulaziz} and Mario Faro and Mahir Gachabayov and {Gim{\'e}nez Maurel}, Teresa and Georgios Gkiokas and Gomes, {Carlos Augusto} and Gonsaga, {Ricardo Alessandro Teixeira} and Gianluca Guercioni and Ali Guner and Sanjay Gupta and Sandra Gutierrez and Martin Hutan and Orestis Ioannidis and Arda Isik and Yoshimitsu Izawa and Jain, {Sumita A.} and Mantas Jokubauskas and Aleksandar Karamarkovic and Saila Kauhanen and Robin Kaushik and Jakub Kenig and Vladimir Khokha and Kim, {Jae Il} and Victor Kong and Renol Koshy and Avidyl Krasniqi and Ashok Kshirsagar and Zygimantas Kuliesius and Konstantinos Lasithiotakis and Pedro Le{\~a}o and Lee, {Jae Gil} and Miguel Leon and {Lizarazu P{\'e}rez}, Aintzane and Varut Lohsiriwat and {L{\'o}pez-Tomassetti Fernandez}, Eudaldo and Eftychios Lostoridis and Raghuveer Mn and Piotr Major and Athanasios Marinis and Daniele Marrelli and Aleix Martinez-Perez and Sanjay Marwah and Michael McFarlane and Melo, {Renato Bessa} and Cristian Mesina and Nick Michalopoulos and Radu Moldovanu and Ouadii Mouaqit and Akutu Munyika and Ionut Negoi and Ioannis Nikolopoulos and Nita, {Gabriela Elisa} and Iyiade Olaoye and Abdelkarim Omari and Ossa, {Paola Rodr{\'i}guez} and Zeynep Ozkan and Ramakrishnapillai Padmakumar and Francesco Pata and {Pereira Junior}, {Gerson Alves} and Jorge Pereira and Tadeja Pintar and Konstantinos Pouggouras and Vinod Prabhu and Stefano Rausei and Miran Rems and Daniel Rios-Cruz and Boris Sakakushev and {S{\'a}nchez de Molina}, {Maria Luisa} and Charampolos Seretis and Vishal Shelat and Sim{\~o}es, {Romeo Lages} and Giovanni Sinibaldi and Matej Skrovina and Dmitry Smirnov and Charalampos Spyropoulos and Jaan Tepp and Tugan Tezcaner and Matti Tolonen and Myftar Torba and Jan Ulrych and Uzunoglu, {Mustafa Yener} and {van Dellen}, David and {van Ramshorst}, {Gabrielle H.} and Giorgio Vasquez and Aur{\'e}lien Venara and Andras Vereczkei and Nereo Vettoretto and Nutu Vlad and Yadav, {Sanjay Kumar} and Yilmaz, {Tongu{\c c} Utku} and Yuan, {Kuo Ching} and Zachariah, {Sanoop Koshy} and Maurice Zida and Justas Zilinskas and Luca Ansaloni",

note = "Publisher Copyright: {\textcopyright} 2015 Sartelli et al.",

year = "2015",

month = dec,

day = "16",

doi = "10.1186/s13017-015-0055-0",

language = "English",

volume = "10",

journal = "World Journal of Emergency Surgery",

issn = "1749-7922",

publisher = "BioMed Central",

number = "1",

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TY - JOUR

T1 - Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections

T2 - A prospective multicentre study (WISS Study)

AU - Sartelli, Massimo

AU - Abu-Zidan, Fikri M.

AU - Catena, Fausto

AU - Griffiths, Ewen A.

AU - Di Saverio, Salomone

AU - Coimbra, Raul

AU - Ordoñez, Carlos A.

AU - Leppaniemi, Ari

AU - Fraga, Gustavo P.

AU - Coccolini, Federico

AU - Agresta, Ferdinando

AU - Abbas, Asrhaf

AU - Abdel Kader, Saleh

AU - Agboola, John

AU - Amhed, Adamu

AU - Ajibade, Adesina

AU - Akkucuk, Seckin

AU - Alharthi, Bandar

AU - Anyfantakis, Dimitrios

AU - Augustin, Goran

AU - Baiocchi, Gianluca

AU - Bala, Miklosh

AU - Baraket, Oussama

AU - Bayrak, Savas

AU - Bellanova, Giovanni

AU - Beltràn, Marcelo A.

AU - Bini, Roberto

AU - Boal, Matthew

AU - Borodach, Andrey V.

AU - Bouliaris, Konstantinos

AU - Branger, Frederic

AU - Brunelli, Daniele

AU - Catani, Marco

AU - Che Jusoh, Asri

AU - Chichom-Mefire, Alain

AU - Cocorullo, Gianfranco

AU - Colak, Elif

AU - Costa, David

AU - Costa, Silvia

AU - Cui, Yunfeng

AU - Curca, Geanina Loredana

AU - Curry, Terry

AU - Das, Koray

AU - Delibegovic, Samir

AU - Demetrashvili, Zaza

AU - Di Carlo, Isidoro

AU - Drozdova, Nadezda

AU - El Zalabany, Tamer

AU - Enani, Mushira Abdulaziz

AU - Faro, Mario

AU - Gachabayov, Mahir

AU - Giménez Maurel, Teresa

AU - Gkiokas, Georgios

AU - Gomes, Carlos Augusto

AU - Gonsaga, Ricardo Alessandro Teixeira

AU - Guercioni, Gianluca

AU - Guner, Ali

AU - Gupta, Sanjay

AU - Gutierrez, Sandra

AU - Hutan, Martin

AU - Ioannidis, Orestis

AU - Isik, Arda

AU - Izawa, Yoshimitsu

AU - Jain, Sumita A.

AU - Jokubauskas, Mantas

AU - Karamarkovic, Aleksandar

AU - Kauhanen, Saila

AU - Kaushik, Robin

AU - Kenig, Jakub

AU - Khokha, Vladimir

AU - Kim, Jae Il

AU - Kong, Victor

AU - Koshy, Renol

AU - Krasniqi, Avidyl

AU - Kshirsagar, Ashok

AU - Kuliesius, Zygimantas

AU - Lasithiotakis, Konstantinos

AU - Leão, Pedro

AU - Lee, Jae Gil

AU - Leon, Miguel

AU - Lizarazu Pérez, Aintzane

AU - Lohsiriwat, Varut

AU - López-Tomassetti Fernandez, Eudaldo

AU - Lostoridis, Eftychios

AU - Mn, Raghuveer

AU - Major, Piotr

AU - Marinis, Athanasios

AU - Marrelli, Daniele

AU - Martinez-Perez, Aleix

AU - Marwah, Sanjay

AU - McFarlane, Michael

AU - Melo, Renato Bessa

AU - Mesina, Cristian

AU - Michalopoulos, Nick

AU - Moldovanu, Radu

AU - Mouaqit, Ouadii

AU - Munyika, Akutu

AU - Negoi, Ionut

AU - Nikolopoulos, Ioannis

AU - Nita, Gabriela Elisa

AU - Olaoye, Iyiade

AU - Omari, Abdelkarim

AU - Ossa, Paola Rodríguez

AU - Ozkan, Zeynep

AU - Padmakumar, Ramakrishnapillai

AU - Pata, Francesco

AU - Pereira Junior, Gerson Alves

AU - Pereira, Jorge

AU - Pintar, Tadeja

AU - Pouggouras, Konstantinos

AU - Prabhu, Vinod

AU - Rausei, Stefano

AU - Rems, Miran

AU - Rios-Cruz, Daniel

AU - Sakakushev, Boris

AU - Sánchez de Molina, Maria Luisa

AU - Seretis, Charampolos

AU - Shelat, Vishal

AU - Simões, Romeo Lages

AU - Sinibaldi, Giovanni

AU - Skrovina, Matej

AU - Smirnov, Dmitry

AU - Spyropoulos, Charalampos

AU - Tepp, Jaan

AU - Tezcaner, Tugan

AU - Tolonen, Matti

AU - Torba, Myftar

AU - Ulrych, Jan

AU - Uzunoglu, Mustafa Yener

AU - van Dellen, David

AU - van Ramshorst, Gabrielle H.

AU - Vasquez, Giorgio

AU - Venara, Aurélien

AU - Vereczkei, Andras

AU - Vettoretto, Nereo

AU - Vlad, Nutu

AU - Yadav, Sanjay Kumar

AU - Yilmaz, Tonguç Utku

AU - Yuan, Kuo Ching

AU - Zachariah, Sanoop Koshy

AU - Zida, Maurice

AU - Zilinskas, Justas

AU - Ansaloni, Luca

PY - 2015/12/16

Y1 - 2015/12/16

N2 - Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.

AB - Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.

KW - Infections

KW - Intra-abdominal

KW - Sepsis

KW - Septic shock

UR - http://www.scopus.com/inward/record.url?scp=84949808332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949808332&partnerID=8YFLogxK

U2 - 10.1186/s13017-015-0055-0

DO - 10.1186/s13017-015-0055-0

M3 - Article

AN - SCOPUS:84949808332

SN - 1749-7922

VL - 10

JO - World Journal of Emergency Surgery

JF - World Journal of Emergency Surgery

IS - 1

M1 - 61

ER -

Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)

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