TY - JOUR
T1 - Gold nanoparticles chemisorbed by a terphenyldithiol self-assembled monolayer for fabrication of a protein biosensor
AU - Al-Rawashdeh, Nathir A.F.
AU - Azzam, W.
N1 - Funding Information:
Acknowledgments N.A.F. Al-Rawashdeh gratefully acknowledges financial support by Jordan University of Science and Technology, Jordan. W. Azzam gratefully acknowledges financial support
PY - 2011/9
Y1 - 2011/9
N2 - In this study, improved detection of bovine serum albumin (BSA) was achieved by use of a fabricated surface plasmon resonance (SPR) biosensor. Terphenyldithiol (TPDT) was self-assembled on a gold substrate, then gold nanoparticles (Au-NPs) were chemisorbed on to the TPDT monolayer by strong bonding with the terminal thiol groups of the TPDT. The new sensor obtained was tested for immobilization of protein. The SPR results revealed much better detection of BSA by Au-NPs chemisorbed on the TPDT self-assembled monolayer (SAM) than by the bare SAM on the gold substrate.
AB - In this study, improved detection of bovine serum albumin (BSA) was achieved by use of a fabricated surface plasmon resonance (SPR) biosensor. Terphenyldithiol (TPDT) was self-assembled on a gold substrate, then gold nanoparticles (Au-NPs) were chemisorbed on to the TPDT monolayer by strong bonding with the terminal thiol groups of the TPDT. The new sensor obtained was tested for immobilization of protein. The SPR results revealed much better detection of BSA by Au-NPs chemisorbed on the TPDT self-assembled monolayer (SAM) than by the bare SAM on the gold substrate.
KW - Gold nanoparticles
KW - Protein biosensor
KW - Self-assembled monolayers
KW - Surface plasmon resonance
KW - Terphenyldithiol
UR - http://www.scopus.com/inward/record.url?scp=80855144190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80855144190&partnerID=8YFLogxK
U2 - 10.1007/s11164-011-0309-8
DO - 10.1007/s11164-011-0309-8
M3 - Article
AN - SCOPUS:80855144190
SN - 0922-6168
VL - 37
SP - 759
EP - 770
JO - Research on Chemical Intermediates
JF - Research on Chemical Intermediates
IS - 7
ER -