Gut hormones in acute diarrhoea

H. S. Besterman; N. D. Christofides; P. D. Welsby; T. E. Adrian; D. L. Sarson; S. R. Bloom

doi:10.1136/gut.24.7.665

Gut hormones in acute diarrhoea

H. S. Besterman, N. D. Christofides, P. D. Welsby, T. E. Adrian, D. L. Sarson, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and prostprandial responses of motilin, enteroglucagon, and vasoactive intestinal polypeptide (VIP) were also significantly greater than controls. No abnormalities in plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP) or pancreatic glucagon were found. The suggested physiological actions of the raised hormones may be relevant to the pathophysiology of diarrhoea.

Original language	English
Pages (from-to)	665-671
Number of pages	7
Journal	Unknown Journal
Volume	24
Issue number	7
DOIs	https://doi.org/10.1136/gut.24.7.665
Publication status	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1136/gut.24.7.665

Cite this

@article{bf97eaf0d0544243be595ba8e6c99ad9,

title = "Gut hormones in acute diarrhoea",

abstract = "The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and prostprandial responses of motilin, enteroglucagon, and vasoactive intestinal polypeptide (VIP) were also significantly greater than controls. No abnormalities in plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP) or pancreatic glucagon were found. The suggested physiological actions of the raised hormones may be relevant to the pathophysiology of diarrhoea.",

author = "Besterman, {H. S.} and Christofides, {N. D.} and Welsby, {P. D.} and Adrian, {T. E.} and Sarson, {D. L.} and Bloom, {S. R.}",

year = "1983",

doi = "10.1136/gut.24.7.665",

language = "English",

volume = "24",

pages = "665--671",

journal = "Unknown Journal",

issn = "1434-8411",

publisher = "Elsevier GmbH",

number = "7",

}

TY - JOUR

T1 - Gut hormones in acute diarrhoea

AU - Besterman, H. S.

AU - Christofides, N. D.

AU - Welsby, P. D.

AU - Adrian, T. E.

AU - Sarson, D. L.

AU - Bloom, S. R.

PY - 1983

Y1 - 1983

N2 - The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and prostprandial responses of motilin, enteroglucagon, and vasoactive intestinal polypeptide (VIP) were also significantly greater than controls. No abnormalities in plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP) or pancreatic glucagon were found. The suggested physiological actions of the raised hormones may be relevant to the pathophysiology of diarrhoea.

AB - The gut hormone response to a breakfast meal was studied in 12 subjects hospitalised for an episode of acute diarrhoea (presumed infective) who were otherwise well and in 13 healthy control subjects. Fasting blood glucose concentrations were low but basal insulin concentrations were raised. Basal concentrations of pancreatic polypeptide and both basal and prostprandial responses of motilin, enteroglucagon, and vasoactive intestinal polypeptide (VIP) were also significantly greater than controls. No abnormalities in plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP) or pancreatic glucagon were found. The suggested physiological actions of the raised hormones may be relevant to the pathophysiology of diarrhoea.

UR - http://www.scopus.com/inward/record.url?scp=0020598193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020598193&partnerID=8YFLogxK

U2 - 10.1136/gut.24.7.665

DO - 10.1136/gut.24.7.665

M3 - Article

C2 - 6345284

AN - SCOPUS:0020598193

SN - 1434-8411

VL - 24

SP - 665

EP - 671

JO - Unknown Journal

JF - Unknown Journal

IS - 7

ER -

Gut hormones in acute diarrhoea

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this