Gut hormones in fetal distress

A. Lucas; T. E. Adrian; A. Aynsley-Green; S. R. Bloom

doi:10.1016/S0140-6736(79)92670-9

Gut hormones in fetal distress

A. Lucas, T. E. Adrian, A. Aynsley-Green, S. R. Bloom

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	968
Number of pages	1
Journal	The Lancet
Volume	314
Issue number	8149
DOIs	https://doi.org/10.1016/S0140-6736(79)92670-9
Publication status	Published - Nov 3 1979
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(79)92670-9

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@article{908ed82825d443c4bf95c776b768f58d,

title = "Gut hormones in fetal distress",

author = "A. Lucas and Adrian, {T. E.} and A. Aynsley-Green and Bloom, {S. R.}",

note = "Funding Information: at the lowest dilution. By contrast, the undiluted serum from a normal individual 22 years after uncomplicated measles gave only faint precipitation of each of the proteins, which had almost disappeared at a dilution of 1:10. The CSF (figure, B) also contained a high titre of antibodies to measles-virus pro-teins, with precipitation of most of the proteins at a dilution of 1:64, but there were only barely detectable antibodies to the M protein at the lowest dilutions. The persistence of high titres of antibodies in the serum and CSF for many years after measles strongly suggests that the patient is still expressing the genetic information of the virus, probably in the central nervous system. Further, the absence of antibodies to the M protein suggests that, as for SSPE,l there is an abnormality in the synthesis or processing of the M protein in the brain. We suggested that the most likely explanation for this in SSPE was decreased synthesis of M, possibly related to a host-determined restriction (i.e., the brain cells do not permit full expression of the virus genome). The finding of deficient synthesis of M in SSPE brain cells in cul- supports hypothesis, finding patient without SSPE. this A high level of as serum does our and CSF antibodies in a to each of the measles virus proteins except M in a patient with a chronic seizure disorder and mental retardation after measles infection 24 years previously further suggests that there may be a spectrum of chronic neurological diseases related to measles virus, rather than persistent infection of the central nervous system being limited to the SSPE syndrome. Further efforts should be devoted to searching for evidence of measles- virus infection and investigating the nature of the antibody re- sponse in certain patients with mental retardation and/or seiz- ure disorders. This work was supported by research grant Multiple Sclerosis Society and AI-05600 from of Allergy and Infectious Diseases. W.W.H. is scholar.",

year = "1979",

month = nov,

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doi = "10.1016/S0140-6736(79)92670-9",

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TY - JOUR

T1 - Gut hormones in fetal distress

AU - Lucas, A.

AU - Adrian, T. E.

AU - Aynsley-Green, A.

AU - Bloom, S. R.

N1 - Funding Information: at the lowest dilution. By contrast, the undiluted serum from a normal individual 22 years after uncomplicated measles gave only faint precipitation of each of the proteins, which had almost disappeared at a dilution of 1:10. The CSF (figure, B) also contained a high titre of antibodies to measles-virus pro-teins, with precipitation of most of the proteins at a dilution of 1:64, but there were only barely detectable antibodies to the M protein at the lowest dilutions. The persistence of high titres of antibodies in the serum and CSF for many years after measles strongly suggests that the patient is still expressing the genetic information of the virus, probably in the central nervous system. Further, the absence of antibodies to the M protein suggests that, as for SSPE,l there is an abnormality in the synthesis or processing of the M protein in the brain. We suggested that the most likely explanation for this in SSPE was decreased synthesis of M, possibly related to a host-determined restriction (i.e., the brain cells do not permit full expression of the virus genome). The finding of deficient synthesis of M in SSPE brain cells in cul- supports hypothesis, finding patient without SSPE. this A high level of as serum does our and CSF antibodies in a to each of the measles virus proteins except M in a patient with a chronic seizure disorder and mental retardation after measles infection 24 years previously further suggests that there may be a spectrum of chronic neurological diseases related to measles virus, rather than persistent infection of the central nervous system being limited to the SSPE syndrome. Further efforts should be devoted to searching for evidence of measles- virus infection and investigating the nature of the antibody re- sponse in certain patients with mental retardation and/or seiz- ure disorders. This work was supported by research grant Multiple Sclerosis Society and AI-05600 from of Allergy and Infectious Diseases. W.W.H. is scholar.

PY - 1979/11/3

Y1 - 1979/11/3

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U2 - 10.1016/S0140-6736(79)92670-9

DO - 10.1016/S0140-6736(79)92670-9

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SN - 0140-6736

VL - 314

SP - 968

JO - The Lancet

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IS - 8149

ER -

Gut hormones in fetal distress

ASJC Scopus subject areas

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