Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol

Lujain Bader Eddin, Niraj Kumar Jha, Sameer N. Goyal, Yogeeta O. Agrawal, Sandeep B. Subramanya, Salim M.A. Bastaki, Shreesh Ojha

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

α-Bisabolol is one of the important monocyclic sesquiterpenes, derived naturally from essential oils of many edible and ornamental plants. It was first obtained from Matricaria chamomilla, commonly known as chamomile or German chamomile. The available literature indicates that this plant along with other α-Bisabolol containing plants is popularly used in traditional medicine for potential health benefits and general wellbeing. Nutritional studies are indicative of the health benefits of α-Bisabolol. Numerous experimental studies demonstrated pharmacological properties of α-Bisabolol including anticancer, antinociceptive, neuroprotective, cardioprotective, and antimicrobial. This review aims to collectively present different pharmacological activities based on both in vitro and in vivo studies. In the present review using synoptic tables and figures, we comprehensively present that α-Bisabolol possesses therapeutic and protective activities, therefore, it can be used for potential health benefits based on pharmacological effects, underlying molecular mechanism, and favorable pharmaceutical properties. Based on the studies mostly performed in cell lines or animal models, it is evident that α-Bisabolol may be a promising nutraceutical and phytomedicine to target aberrant biological mechanisms which result in altered physiological processes and various ailments. Given the polypharmacological effects and pleiotropic properties, along with favorable pharmacokinetics, and dietary availability and safety, α-Bisabolol can be used as a dietary agent, nutraceutical or phytopharmaceutical agent or as an adjuvant with currently available modern medicines. The regulatory approval of this molecule for use as food additives, and in cosmetics and fragrance industry is also supportive of its human usage. Moreover, further studies are necessary to address pharmaceutical, pharmacological, and toxicological aspects before clinical or nutritional usage in humans. The pharmacological effects and biological actions opens up opportunities on the pharmacological basis of its use in future therapeutics.

Original languageEnglish
Article number1370
JournalNutrients
Volume14
Issue number7
DOIs
Publication statusPublished - Apr 1 2022

Keywords

  • German chamomile tea
  • natural products
  • pharmacology
  • phytochemicals
  • sesquiterpene
  • α-Bisabolol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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