Health risk of inhaled (nano)-particles

The effect of inhaled particles on haemostasis and cardiovascular endpoints such as thrombosis was studied. Two complementary hypotheses were proposed to explain cardiovascular dysfunction after inhalation of ultrafine particles. It has been shown that within an hour after the deposition of diesel exhaust particle (DEP) in the lungs, both a marked pulmonary inflammation and enhanced femoral venous and arterial thrombosis are apparent. The results indicate that nano-sized particles can, after the passage into the circulation, also play a role, and therefore rapid interact with cardiovascular functions such as thrombogenesis.