Heart Rate Variability Time Analyses of the Streptozotocin-Diabetic Rat

M. Jacobson, F. C. Howarth, E. Adeghate, K. Fatima-Shad

Research output: Contribution to journalArticlepeer-review


As the world prevalence of diabetes mellitus (DM) increases, animal models of the disease's progression are required for researching effective treatment. The streptozotocin (STZ) treated rat is known to cause hyperglycaemia. This study confirms that this animal model also displays DM physiological effects in the animal heart rate (HR) and heart rate variability (HRV). In particular, 5 minutes of rat (n=13) electrocardiogram (ECG) is acquired hourly for 30 days. At day 10, the animal (n=7) is dosed with STZ and the ECG is analyzed in order to determine the HR and HRV. The HRV is indexed using two time-based analyses, based on long-term (24hr) and short-term (5min) analyses. All analyses are compared to control non-STZ dosed animals (n=6) and display significant DM effects.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalJournal of Engineering Research
Issue number1
Publication statusPublished - 2017


  • Heart tate variability
  • Streptozotocin-Diabetic
  • Time-domain analysis

ASJC Scopus subject areas

  • General Engineering


Dive into the research topics of 'Heart Rate Variability Time Analyses of the Streptozotocin-Diabetic Rat'. Together they form a unique fingerprint.

Cite this