TY - JOUR
T1 - Heart Rate Variability Time Analyses of the Streptozotocin-Diabetic Rat
AU - Jacobson, M.
AU - Howarth, F. C.
AU - Adeghate, E.
AU - Fatima-Shad, K.
N1 - Publisher Copyright:
© 2017, Journal of Engineering Research. All Rights Reserved.
PY - 2017
Y1 - 2017
N2 - As the world prevalence of diabetes mellitus (DM) increases, animal models of the disease's progression are required for researching effective treatment. The streptozotocin (STZ) treated rat is known to cause hyperglycaemia. This study confirms that this animal model also displays DM physiological effects in the animal heart rate (HR) and heart rate variability (HRV). In particular, 5 minutes of rat (n=13) electrocardiogram (ECG) is acquired hourly for 30 days. At day 10, the animal (n=7) is dosed with STZ and the ECG is analyzed in order to determine the HR and HRV. The HRV is indexed using two time-based analyses, based on long-term (24hr) and short-term (5min) analyses. All analyses are compared to control non-STZ dosed animals (n=6) and display significant DM effects.
AB - As the world prevalence of diabetes mellitus (DM) increases, animal models of the disease's progression are required for researching effective treatment. The streptozotocin (STZ) treated rat is known to cause hyperglycaemia. This study confirms that this animal model also displays DM physiological effects in the animal heart rate (HR) and heart rate variability (HRV). In particular, 5 minutes of rat (n=13) electrocardiogram (ECG) is acquired hourly for 30 days. At day 10, the animal (n=7) is dosed with STZ and the ECG is analyzed in order to determine the HR and HRV. The HRV is indexed using two time-based analyses, based on long-term (24hr) and short-term (5min) analyses. All analyses are compared to control non-STZ dosed animals (n=6) and display significant DM effects.
KW - Heart tate variability
KW - Streptozotocin-Diabetic
KW - Time-domain analysis
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U2 - 10.24200/TJER.VOL4ISS1PP64-68
DO - 10.24200/TJER.VOL4ISS1PP64-68
M3 - Article
AN - SCOPUS:85120958548
SN - 1726-6009
VL - 4
SP - 64
EP - 68
JO - Journal of Engineering Research
JF - Journal of Engineering Research
IS - 1
ER -
