TY - JOUR
T1 - Hepatitis B virus transmission in The Netherlands
T2 - A population-based, hierarchical case-control study in a very low-incidence country
AU - Hahné, Susan J.M.
AU - Veldhuijzen, I. K.
AU - Smits, L. J.M.
AU - Nagelkerke, N.
AU - van de Laar, M. J.W.
PY - 2008/2
Y1 - 2008/2
N2 - We report the first population-based case-control study on acute hepatitis B in a very low-incidence country. A case was a Netherlands resident, notified between May 1999 and July 2000 with symptoms and serology compatible with acute hepatitis B. Population controls were randomly selected, with oversampling from men and persons aged 20-39 years. Risk factors were studied using logistical regression, distinguishing confounders and mediators through hierarchical analysis. Participants were 120 cases and 3948 controls. The risk of acute hepatitis B was increased in men who have sex with men, with reporting to have had more than two partners in the past 6 months the only significant risk. In children, adult females and heterosexual males, having parents born in a hepatitis B endemic country was a significant risk. For adult females and heterosexual males, this was largely explained by having a foreign partner. For children this was partly explained by parenteral exposures abroad.
AB - We report the first population-based case-control study on acute hepatitis B in a very low-incidence country. A case was a Netherlands resident, notified between May 1999 and July 2000 with symptoms and serology compatible with acute hepatitis B. Population controls were randomly selected, with oversampling from men and persons aged 20-39 years. Risk factors were studied using logistical regression, distinguishing confounders and mediators through hierarchical analysis. Participants were 120 cases and 3948 controls. The risk of acute hepatitis B was increased in men who have sex with men, with reporting to have had more than two partners in the past 6 months the only significant risk. In children, adult females and heterosexual males, having parents born in a hepatitis B endemic country was a significant risk. For adult females and heterosexual males, this was largely explained by having a foreign partner. For children this was partly explained by parenteral exposures abroad.
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U2 - 10.1017/S0950268807008205
DO - 10.1017/S0950268807008205
M3 - Article
C2 - 17407622
AN - SCOPUS:38049168692
SN - 0950-2688
VL - 136
SP - 184
EP - 195
JO - Journal of Hygiene
JF - Journal of Hygiene
IS - 2
ER -