Abstract
Aim: To evaluate the protective effects of ginger (Gin) and roselle (Ros) against testicular damage and oxidative stress in a cisplatin (CIS)-induced rodent model. Their protective effects against CIS-induced apoptosis in testicular and epididymal sperms is also investigated. Methods: Ethanol extracts of Gin or Ros (1 g/kg·day) were given orally to male albino rats for 26 days. This period began 21 days before a single CIS intraperitoneal injection (10 mg/kg body weight). Results: Gin or Ros given orally significantly restored reproductive function. Both tested extracts notably reduced the CIS-induced reproductive toxicity, as evidenced by restoring the testis normal morphology. In Gin and Ros, the attenuation of CIS-induced damage was associated with less apoptotic cell death both in the testicular tissue and in the sperms. CIS-induced alterations of testicular lipid peroxidation were markedly improved by these plant extracts. Conclusion: The present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential anti-oxidant potential of both examined extracts.
Original language | English |
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Pages (from-to) | 291-297 |
Number of pages | 7 |
Journal | Asian Journal of Andrology |
Volume | 10 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 1 2008 |
Keywords
- Cell death
- Cisplatin
- Flow cytometry
- Ginger
- Roselle
- Toxicity
ASJC Scopus subject areas
- Urology