Heterogeneity in host HIV susceptibility as a potential contributor to recent HIV prevalence declines in Africa

Nico J.D. Nagelkerke, Sake J. De Vlas, Prabhat Jha, Ma Luo, Francis A. Plummer, Rupert Kaul

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Background: HIV prevalence has recently declined in several African countries, and prior to this the risk of HIV acquisition per unprotected sex contact also declined in Kenyan sex workers. We hypothesized that heterogeneity in HIV host susceptibility might underpin both of these observations. Methods: A compartmental mathematical model was used to explore the potential impact of heterogeneity in susceptibility to HIV infection on epidemic behavior, in the absence of other causative mechanisms. Results: Studies indicated that a substantial heterogeneity in susceptibility to HIV infection may lead to an epidemic that peaks and then declines due to a depletion of the most susceptible individuals, even without changes in sexual behavior. This effect was most notable in high-risk groups such as female sex workers and was consistent with empirical data. Discussion: Declines in HIV prevalence may have other causes in addition to behavior change, including heterogeneity in host HIV susceptibility. There is a need to further study this heterogeneity and its correlates, particularly as it confounds the ability to attribute HIV epidemic shifts to specific interventions, including behavior change.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
Issue number1
Publication statusPublished - Jan 2 2009
Externally publishedYes


  • Epidemiology
  • HIV transmission
  • Heterogeneity in host susceptibility
  • Modeling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


Dive into the research topics of 'Heterogeneity in host HIV susceptibility as a potential contributor to recent HIV prevalence declines in Africa'. Together they form a unique fingerprint.

Cite this