HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort

Lyle R. McKinnon; Nico J. Nagelkerke; Rupert Kaul; Souradet Y. Shaw; Rupert Capina; Ma Luo; Anthony Kariri; Winnie Apidi; Makobu Kimani; Charles Wachihi; Walter Jaoko; A. Omu Anzala; Joshua Kimani; T. Blake Ball; Francis A. Plummer

doi:10.1371/journal.pone.0049797

HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort

Lyle R. McKinnon, Nico J. Nagelkerke, Rupert Kaul, Souradet Y. Shaw, Rupert Capina, Ma Luo, Anthony Kariri, Winnie Apidi, Makobu Kimani, Charles Wachihi, Walter Jaoko, A. Omu Anzala, Joshua Kimani, T. Blake Ball, Francis A. Plummer

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.

Original language	English
Article number	e49797
Journal	PLoS ONE
Volume	7
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0049797
Publication status	Published - Nov 21 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General

Access to Document

10.1371/journal.pone.0049797

Cite this

@article{0eeea381ada949199c6385ef7d020837,

title = "HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort",

abstract = "HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of {"}protective{"} HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.",

author = "McKinnon, {Lyle R.} and Nagelkerke, {Nico J.} and Rupert Kaul and Shaw, {Souradet Y.} and Rupert Capina and Ma Luo and Anthony Kariri and Winnie Apidi and Makobu Kimani and Charles Wachihi and Walter Jaoko and Anzala, {A. Omu} and Joshua Kimani and Ball, {T. Blake} and Plummer, {Francis A.}",

year = "2012",

month = nov,

day = "21",

doi = "10.1371/journal.pone.0049797",

language = "English",

volume = "7",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "11",

}

TY - JOUR

T1 - HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort

AU - McKinnon, Lyle R.

AU - Nagelkerke, Nico J.

AU - Kaul, Rupert

AU - Shaw, Souradet Y.

AU - Capina, Rupert

AU - Luo, Ma

AU - Kariri, Anthony

AU - Apidi, Winnie

AU - Kimani, Makobu

AU - Wachihi, Charles

AU - Jaoko, Walter

AU - Anzala, A. Omu

AU - Kimani, Joshua

AU - Ball, T. Blake

AU - Plummer, Francis A.

PY - 2012/11/21

Y1 - 2012/11/21

N2 - HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.

AB - HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.

UR - http://www.scopus.com/inward/record.url?scp=84869832951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869832951&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0049797

DO - 10.1371/journal.pone.0049797

M3 - Article

C2 - 23185441

AN - SCOPUS:84869832951

SN - 1932-6203

VL - 7

JO - PLoS One

JF - PLoS One

IS - 11

M1 - e49797

ER -

HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this