Abstract
HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.
| Original language | English |
|---|---|
| Pages (from-to) | 703-710 |
| Number of pages | 8 |
| Journal | Acta Chromatographica |
| Volume | 25 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 1 2013 |
Keywords
- HPLC
- K027
- blood-brain barrier
- pharmacokinetics
- quantitation
- reversed-phase separation
ASJC Scopus subject areas
- General Chemistry