TY - JOUR
T1 - Human Immunodeficiency Virus Infection among High-Risk Seronegative Prostitutes in Nairobi
AU - Willerford, Dennis M.
AU - Bwayo, Job J.
AU - Hensel, Michelle
AU - Emonyi, Wilfred
AU - Plummer, Francis A.
AU - Ngugi, Elizabeth N.
AU - Nagelkerke, Nico
AU - Gallatin, W. Michael
AU - Kreiss, Joan
AU - Willerford, Dennis M.
AU - Bwayo, Job J.
AU - Hensel, Michelle
AU - Emonyi, Wilfred
AU - Ngugi, Elizabeth N.
AU - Gallatin, W. Michael
AU - Kreiss, Joan
AU - Willerford, Dennis M.
AU - Bwayo, Job J.
AU - Hensel, Michelle
AU - Emonyi, Wilfred
AU - Ngugi, Elizabeth N.
AU - Gallatin, W. Michael
AU - Kreiss, Joan
AU - Willerford, Dennis M.
AU - Bwayo, Job J.
AU - Hensel, Michelle
AU - Emonyi, Wilfred
AU - Ngugi, Elizabeth N.
AU - Gallatin, W. Michael
AU - Kreiss, Joan
AU - Gallatin, W. Michael
N1 - Funding Information:
Financial Support: National Institutes ofHealth (NIH; AI-25024); Medical Research Council of Canada (SP27 and Scientist award to F.A.P.). D.M.W. was a research fellow of the American Heart Association. J.B. and W.E. were scholars in the International AIDS Research and Training Program, supported by the Fogarty International Center, NIH (T22-TWOOOO I and D43-TW00007, respectively).
PY - 1993/6
Y1 - 1993/6
N2 - To determine the frequency and duration of antibody-negative human immunodeficiency virus (HIV) infection among heterosexually exposed African women, 56 HIV-seronegative female prostitutes in Nairobi were studied. Polymerase chain reaction (peR) was used to detect HIV DNA in peripheral blood at enrollment, and women were followed prospectively with serologic testing to determine HIV seroincidence. Six women (11%) were infected with HIV by peR criteria at enrollment. Seroconversion occurred in 5 of these subjects within 1-12 months, while the sixth remained seronegative when last evaluated at 5 months. The cumulative annual seroconversion rate in the entire cohort was 38%. Using maximum likelihood analysis, the mean interval between HIV infection and seroconversion was estimated to be between 3 and 4 months, similar to that described for homosexual men and blood product recipients in the United States. Prolonged HIV infection in the absence of antibodies appears to be uncommon in this setting.
AB - To determine the frequency and duration of antibody-negative human immunodeficiency virus (HIV) infection among heterosexually exposed African women, 56 HIV-seronegative female prostitutes in Nairobi were studied. Polymerase chain reaction (peR) was used to detect HIV DNA in peripheral blood at enrollment, and women were followed prospectively with serologic testing to determine HIV seroincidence. Six women (11%) were infected with HIV by peR criteria at enrollment. Seroconversion occurred in 5 of these subjects within 1-12 months, while the sixth remained seronegative when last evaluated at 5 months. The cumulative annual seroconversion rate in the entire cohort was 38%. Using maximum likelihood analysis, the mean interval between HIV infection and seroconversion was estimated to be between 3 and 4 months, similar to that described for homosexual men and blood product recipients in the United States. Prolonged HIV infection in the absence of antibodies appears to be uncommon in this setting.
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U2 - 10.1093/infdis/167.6.1414
DO - 10.1093/infdis/167.6.1414
M3 - Article
C2 - 8501333
AN - SCOPUS:0027286368
SN - 0022-1899
VL - 167
SP - 1414
EP - 1417
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -