TY - JOUR
T1 - Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran
AU - Landberg, Rikard
AU - Linko, Anna Maria
AU - Kamal-Eldin, Afaf
AU - Vessby, Bengt
AU - Adlercreutz, Herman
AU - Åman, Per
PY - 2006/11
Y1 - 2006/11
N2 - Alkylresorcinols (ARs) are phenolic lipids present in whole grain and bran of wheat and rye. Chemically, they comprise 1,3-dihydroxy-5-alkylbenzene homologs with odd-numbered, mainly saturated hydrocarbon side chains in the range of 17-25 carbon atoms. ARs are evaluated both for physiological effects and for their potential use as biomarkers of whole-grain wheat and rye intake. In this study, plasma kinetics and relative bioavailability of ARs in humans were investigated after a single intake of rye bran 120 g (190 mg ARs). The shapes of plasma concentration time curves were similar in the subjects (n = 6) with 2 peaks at ∼2.8 and 6.5 h and maximum concentrations (mean ± SEM) of 1253 ± 125 and 3365 ± 309 nmol/L, respectively. The relative bioavailability of different homologs increased with increasing length of the AR side chain (r = 0.97, P < 0.001), indicating differences in metabolism. The apparent half-lives were rather short, ∼5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and rye.
AB - Alkylresorcinols (ARs) are phenolic lipids present in whole grain and bran of wheat and rye. Chemically, they comprise 1,3-dihydroxy-5-alkylbenzene homologs with odd-numbered, mainly saturated hydrocarbon side chains in the range of 17-25 carbon atoms. ARs are evaluated both for physiological effects and for their potential use as biomarkers of whole-grain wheat and rye intake. In this study, plasma kinetics and relative bioavailability of ARs in humans were investigated after a single intake of rye bran 120 g (190 mg ARs). The shapes of plasma concentration time curves were similar in the subjects (n = 6) with 2 peaks at ∼2.8 and 6.5 h and maximum concentrations (mean ± SEM) of 1253 ± 125 and 3365 ± 309 nmol/L, respectively. The relative bioavailability of different homologs increased with increasing length of the AR side chain (r = 0.97, P < 0.001), indicating differences in metabolism. The apparent half-lives were rather short, ∼5 h for all homologs, which suggests that the AR concentration in plasma could be used as a short- to medium-term biomarker of regular intake of whole-grain wheat and rye.
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U2 - 10.1093/jn/136.11.2760
DO - 10.1093/jn/136.11.2760
M3 - Article
C2 - 17056797
AN - SCOPUS:33751107487
SN - 0022-3166
VL - 136
SP - 2760
EP - 2765
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 11
ER -