Humoral growth factors in plasma and liver tissue during liver regeneration and malnutrition

Stefan Skullman, Thomas E. Adrian, Johan Permert, Jörgen Larsson

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective: To investigate the potential of a series of growth factors which may be involved in liver regeneration. Design: The concentrations of epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and insulin-like growth factor I (IGF-I) were measured in plasma and liver tissue 48h after liver resection or sham operation combined with malnutrition. Methods: Forty-four rats were randomized to either semistarvation or ordinary food intake; half of each group was partially hepatectomized, and the other half underwent a sham operation and served as controls. Growth factors were measured by radioimmunoassay. Results: Plasma EGF levels were increased following semistarvation and were also increased in plasma and liver tissue after 48 h of liver regeneration. Tumour necrosis factor-alpha levels did not change following either malnutrition or liver regeneration. Insulin-like growth factor I levels were raised in liver tissue after 48 h of regeneration.Conclusion: These results suggest that EGF has a central role in liver regeneration; the role of IGF-I is uncertain, while TGF-alpha does not seem to be involved in regeneration at 48 h.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number9
Publication statusPublished - Sept 1994
Externally publishedYes


  • Epidermal growth factor
  • Insulin-like growth factor I
  • Liver regeneration
  • Malnutrition
  • Transforming growth factor-alpha

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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