Hyperdiluted calcium hydroxylapatite for the treatment of skin laxity of the neck

Stefania Guida, Sabrina Longhitano, Marco Spadafora, Andrea Lazzarotto, Francesca Farnetani, Nicola Zerbinati, Giovanni Pellacani, Hassan Galadari

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Despite being a common concern, there are very few minimally invasive treatments targeting neck skin laxity (NSL) reported in the literature. To assess the efficacy of hyperdiluted calcium hydroxyapatite (hy-CaHA) for the treatment of NSL, according to the NSL scale, and to estimate safety. Twenty patients showing NSL were treated with hy-CaHA 1:2. To evaluate the efficacy of hy-CaHA treatment for NSL, pictures of treated subjects were collected before and 3 months after treatment and graded according to the NSL scale, and T-student's test was applied to estimate differences. Hy-CaHA for the neck was effective according to the previously unreported NSL scale (p < 0.001) and safe. There were no major adverse events reported. This study supports the efficacy (according to the NSL scale) and safety of hy-CaHA (1:2) for NSL. Our results also highlight the utility of the newly developed NSL scale, being a useful tool to evaluate the level of NSL before treatment and to measure the outcome.

Original languageEnglish
Article numbere15090
JournalDermatologic Therapy
Issue number5
Publication statusPublished - Sept 1 2021


  • calcium hydroxylapatite
  • hyperdiluted calcium hydroxylapatite
  • neck
  • neck skin laxity
  • skin laxity

ASJC Scopus subject areas

  • Dermatology


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