Hypothalamic Hamartomas: A Comprehensive Review of Literature – Part 3: Updates on Radiotherapy Management

Safwan O. Alomari, Mohammed N. El Houshiemy, Shadi Bsat, Charbel K. Moussalem, Mohammed Allouh, Ibrahim A. Omeis

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000 to 1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment and behavioral changes. In this review, the authors discuss the recent advancements in different modalities of radiotherapy and their application in hypothalamic hamartomas management.

Original languageEnglish
Article number106077
JournalClinical Neurology and Neurosurgery
Publication statusPublished - Oct 2020


  • Gamma knife surgery (GKS)
  • Laser interstitial thermal therapy (LITT) / Stereotactic laser ablation (SLA)
  • Linear accelerator stereotactic radiosurgery (LINAC)
  • Stereotactic radiofrequency thermoregulation (SRT)
  • Stereotactic radiosurgery (SRS)

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Hypothalamic Hamartomas: A Comprehensive Review of Literature – Part 3: Updates on Radiotherapy Management'. Together they form a unique fingerprint.

Cite this