TY - JOUR
T1 - Hypothalamic Hamartomas
T2 - A Comprehensive Review of Literature – Part 3: Updates on Radiotherapy Management
AU - Alomari, Safwan O.
AU - El Houshiemy, Mohammed N.
AU - Bsat, Shadi
AU - Moussalem, Charbel K.
AU - Allouh, Mohammed
AU - Omeis, Ibrahim A.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000 to 1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment and behavioral changes. In this review, the authors discuss the recent advancements in different modalities of radiotherapy and their application in hypothalamic hamartomas management.
AB - Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000 to 1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment and behavioral changes. In this review, the authors discuss the recent advancements in different modalities of radiotherapy and their application in hypothalamic hamartomas management.
KW - Gamma knife surgery (GKS)
KW - Laser interstitial thermal therapy (LITT) / Stereotactic laser ablation (SLA)
KW - Linear accelerator stereotactic radiosurgery (LINAC)
KW - Stereotactic radiofrequency thermoregulation (SRT)
KW - Stereotactic radiosurgery (SRS)
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U2 - 10.1016/j.clineuro.2020.106077
DO - 10.1016/j.clineuro.2020.106077
M3 - Review article
C2 - 32717560
AN - SCOPUS:85088402690
SN - 0303-8467
VL - 197
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
M1 - 106077
ER -