Hypothalamic Hamartomas: A comprehensive review of literature – Part 2: Medical and surgical management update

Safwan O. Alomari, Mohamad N. El Houshiemy, Shadi Bsat, Charbel K. Moussalem, Mohammed Allouh, Ibrahim A. Omeis

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000 to 1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment and behavioral changes. In this review, the authors discuss the recent advancements in the medical and surgical management of hypothalamic hamartoma that have been achieved over the past few decades. This review also discusses the advantages and disadvantages of each surgical line of management and factors determining the best individualized approach.

Original languageEnglish
Article number106074
JournalClinical Neurology and Neurosurgery
Volume195
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Corpus callosotomy
  • Endoscopic surgery
  • Frontal/Temporal corticectomy
  • Hypothalamic hamartoma (HH)
  • Transcallosal approach

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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