TY - JOUR
T1 - Hypothalamic hamartomas
T2 - A comprehensive review of the literature – Part 1: Neurobiological features, clinical presentations and advancements in diagnostic tools
AU - Alomari, Safwan O.
AU - Houshiemy, Mohammed N.El
AU - Bsat, Shadi
AU - Moussalem, Charbel K.
AU - Allouh, Mohammed
AU - Omeis, Ibrahim A.
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10
Y1 - 2020/10
N2 - Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000–1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment, and behavioral changes. In this review, the authors discuss advancements in different diagnostic elements of hypothalamic hamartoma; including clinical features, EEG findings, and neuroimaging techniques. Moreover, different classifications described in the literature will be discussed.
AB - Hypothalamic hamartomas (HH) are rare, non-neoplastic heterotopic tissues which contains normal neurons and glia including oligodendrocytes and fibrillary astrocytes but in an abnormal distribution. They arise from the floor of the third ventricle, tuber cinereum, or mammillary bodies. Estimated incidence ranges from 1 in 50,000–1 in 1,000,000. Hypothalamic hamartomas are associated with different clinical presentations including various types of seizures, most characteristically; the gelastic seizures, precocious puberty, cognitive impairment, and behavioral changes. In this review, the authors discuss advancements in different diagnostic elements of hypothalamic hamartoma; including clinical features, EEG findings, and neuroimaging techniques. Moreover, different classifications described in the literature will be discussed.
KW - Gelastic seizures
KW - Hypothalamic hamartoma (HH)
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U2 - 10.1016/j.clineuro.2020.106076
DO - 10.1016/j.clineuro.2020.106076
M3 - Review article
C2 - 32717559
AN - SCOPUS:85088373877
SN - 0303-8467
VL - 197
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
M1 - 106076
ER -