Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats

I. Ahmed; M. S. Lakhani; M. Gillett; A. John; H. Raza

doi:10.1016/S0168-8227(00)00224-2

Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats

I. Ahmed, M. S. Lakhani, M. Gillett, A. John, H. Raza

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

227 Citations (Scopus)

Abstract

Momordica charantia (karela) is commonly used as an antidiabetic and antihyperglycemic agent in Asian, Oriental and Latin American countries. This study was undertaken to investigate the effects of long term feeding (10 weeks) of M. charantia fruit extract on blood plasma and tissue lipid profiles in normal and streptozotocin (STZ) -induced Type 1 diabetic rats. The results show that there was a significant (P<0.05) increase in plasma non-esterified cholesterol, triglycerides and phospholipids in STZ-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL) -cholesterol. A moderate increase in plasma (LPO) product, malonedialdehyde (MDA), and about two-fold increase in kidney LPO was also observed in STZ-induced diabetic rats. The treatment of diabetic rats with M. charantia fruit extract over a 10-week period returned these levels close to normal. In addition, karela juice also exhibited an inhibitory effect on membrane LPO under in vitro conditions. These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat.

Original language	English
Pages (from-to)	155-161
Number of pages	7
Journal	Diabetes Research and Clinical Practice
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/S0168-8227(00)00224-2
Publication status	Published - 2001

Keywords

Cholesterol
Lipid peroxidation
Momordica charantia
Rat
Triglycerides

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/S0168-8227(00)00224-2

Cite this

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title = "Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats",

abstract = "Momordica charantia (karela) is commonly used as an antidiabetic and antihyperglycemic agent in Asian, Oriental and Latin American countries. This study was undertaken to investigate the effects of long term feeding (10 weeks) of M. charantia fruit extract on blood plasma and tissue lipid profiles in normal and streptozotocin (STZ) -induced Type 1 diabetic rats. The results show that there was a significant (P<0.05) increase in plasma non-esterified cholesterol, triglycerides and phospholipids in STZ-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL) -cholesterol. A moderate increase in plasma (LPO) product, malonedialdehyde (MDA), and about two-fold increase in kidney LPO was also observed in STZ-induced diabetic rats. The treatment of diabetic rats with M. charantia fruit extract over a 10-week period returned these levels close to normal. In addition, karela juice also exhibited an inhibitory effect on membrane LPO under in vitro conditions. These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat.",

keywords = "Cholesterol, Lipid peroxidation, Momordica charantia, Rat, Triglycerides",

author = "I. Ahmed and Lakhani, {M. S.} and M. Gillett and A. John and H. Raza",

note = "Funding Information: We wish to thank Professor D.J. Pallot and Dr A. K. Sharma, Department of Anatomy, FMHS, UAE University for their support and encouragement. We are also indebted to M. Shafiuallah, Animal House Facility, FMHS, UAE University for taking care of the experimental animals. This study was supported by a grant from FMHS Research Committee, UAE University.",

year = "2001",

doi = "10.1016/S0168-8227(00)00224-2",

language = "English",

volume = "51",

pages = "155--161",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

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number = "3",

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TY - JOUR

T1 - Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats

AU - Ahmed, I.

AU - Lakhani, M. S.

AU - Gillett, M.

AU - John, A.

AU - Raza, H.

N1 - Funding Information: We wish to thank Professor D.J. Pallot and Dr A. K. Sharma, Department of Anatomy, FMHS, UAE University for their support and encouragement. We are also indebted to M. Shafiuallah, Animal House Facility, FMHS, UAE University for taking care of the experimental animals. This study was supported by a grant from FMHS Research Committee, UAE University.

PY - 2001

Y1 - 2001

N2 - Momordica charantia (karela) is commonly used as an antidiabetic and antihyperglycemic agent in Asian, Oriental and Latin American countries. This study was undertaken to investigate the effects of long term feeding (10 weeks) of M. charantia fruit extract on blood plasma and tissue lipid profiles in normal and streptozotocin (STZ) -induced Type 1 diabetic rats. The results show that there was a significant (P<0.05) increase in plasma non-esterified cholesterol, triglycerides and phospholipids in STZ-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL) -cholesterol. A moderate increase in plasma (LPO) product, malonedialdehyde (MDA), and about two-fold increase in kidney LPO was also observed in STZ-induced diabetic rats. The treatment of diabetic rats with M. charantia fruit extract over a 10-week period returned these levels close to normal. In addition, karela juice also exhibited an inhibitory effect on membrane LPO under in vitro conditions. These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat.

AB - Momordica charantia (karela) is commonly used as an antidiabetic and antihyperglycemic agent in Asian, Oriental and Latin American countries. This study was undertaken to investigate the effects of long term feeding (10 weeks) of M. charantia fruit extract on blood plasma and tissue lipid profiles in normal and streptozotocin (STZ) -induced Type 1 diabetic rats. The results show that there was a significant (P<0.05) increase in plasma non-esterified cholesterol, triglycerides and phospholipids in STZ-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL) -cholesterol. A moderate increase in plasma (LPO) product, malonedialdehyde (MDA), and about two-fold increase in kidney LPO was also observed in STZ-induced diabetic rats. The treatment of diabetic rats with M. charantia fruit extract over a 10-week period returned these levels close to normal. In addition, karela juice also exhibited an inhibitory effect on membrane LPO under in vitro conditions. These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat.

KW - Cholesterol

KW - Lipid peroxidation

KW - Momordica charantia

KW - Rat

KW - Triglycerides

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Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats

Abstract

Keywords

ASJC Scopus subject areas

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