Hypotrypsinaemia in diabetes mellitus

T. E. Adrian, A. J. Barnes, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Plasma trypsin concentrations were measured in 403 fasting diabetics and 106 healthy controls. Basal trypsin concentrations in the normal subjects were 88 ± 6 ng/ml (mean ± S.E.M.). Mean plasma trypsin concentrations in diabetics treated with diet alone (n = 74) were 45 ± 2 ng/ml, while in a group of young ( < 35 years, n = 88) insulin-dependent diabetics, they were very low at 29 ± 2 ng/ml and these levels were inversely related to insulin dosage. The findings may help in the understanding of the pathophysiological changes in the exocrine pancreas in the diabetic state and may also shed some light on the physiological interrelationship between the endocrine and exocrine pancreas.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalClinica Chimica Acta
Issue number2-3
Publication statusPublished - Oct 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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