Identification of a Drosophila prolyl endopeptidase and analysis of its expression

Amr Amin, Yuebing Li, Robert Finkelstein

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Prolyl endopeptidases (PEPs) are believed to be involved in the metabolism of neuropeptide hormones (reviewed in Mentlein [1988]). Genes encoding PEPs have been isolated from various species, but their expression patterns during development have not been determined. In this study, we isolated a gene encoding a predicted PEP from the fruitfly Drosophila melanogaster. The gene encodes a predicted 756-amino acid protein having extensive sequence similarity to human PEP. We demonstrated that the Drosophila gene (DPEP) is expressed in a spatially restricted pattern in imaginal discs and the larval brain. Our results suggest a role for DPEP in the regional specification of larval tissues. They also provide a starting point for a genetic analysis of the function of this enzyme during development.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalDNA and Cell Biology
Issue number8
Publication statusPublished - Aug 1999
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology


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