IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis

Rui Sheng Duan; Xing Mei Zhang; Eilhard Mix; Hernan Concha Quezada; Abdu Adem; Jie Zhu

doi:10.1016/j.jneuroim.2006.12.001

IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis

Rui Sheng Duan, Xing Mei Zhang, Eilhard Mix, Hernan Concha Quezada, Abdu Adem, Jie Zhu

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

IL-18 deficient (IL-18^-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18^-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-γ, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18^-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.

Original language	English
Pages (from-to)	162-167
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	183
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.12.001
Publication status	Published - Feb 2007

Keywords

EAN
IL-18
Th1 cytokines
Th2 cytokines

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2006.12.001

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title = "IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis",

abstract = "IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-γ, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.",

keywords = "EAN, IL-18, Th1 cytokines, Th2 cytokines",

author = "Duan, {Rui Sheng} and Zhang, {Xing Mei} and Eilhard Mix and Quezada, {Hernan Concha} and Abdu Adem and Jie Zhu",

note = "Funding Information: This study was supported by grants from the Swedish Medical Research Council (K2004–33X-13133–06A), Swedish National Board of Health and Welfare, Swedish Medical Association, the Federal Ministry of Education and Research of Germany (BMBF, 01 ZZ 0108) and of the Ministry of Education, Science and Culture of Mecklenburg-Vorpommern, Germany, as well as the funds from United Arab Emirates University Faculty of Medicine and Health Sciences Faculty Grant and from United Arab Emirates University Individual Grant.",

year = "2007",

month = feb,

doi = "10.1016/j.jneuroim.2006.12.001",

language = "English",

volume = "183",

pages = "162--167",

journal = "Journal of Neuroimmunology",

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T1 - IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis

AU - Duan, Rui Sheng

AU - Zhang, Xing Mei

AU - Mix, Eilhard

AU - Quezada, Hernan Concha

AU - Adem, Abdu

AU - Zhu, Jie

N1 - Funding Information: This study was supported by grants from the Swedish Medical Research Council (K2004–33X-13133–06A), Swedish National Board of Health and Welfare, Swedish Medical Association, the Federal Ministry of Education and Research of Germany (BMBF, 01 ZZ 0108) and of the Ministry of Education, Science and Culture of Mecklenburg-Vorpommern, Germany, as well as the funds from United Arab Emirates University Faculty of Medicine and Health Sciences Faculty Grant and from United Arab Emirates University Individual Grant.

PY - 2007/2

Y1 - 2007/2

N2 - IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-γ, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.

AB - IL-18 deficient (IL-18-/-) mice were used to investigate the role of IL-18 in the pathogenesis of experimental autoimmune neuritis (EAN) which was induced by immunization of the mice with P0 protein peptide 180-199. The clinical course was not different between IL-18-/- and wild-type mice. The splenic mononuclear cell (MNC) proliferation was also similar in both animal groups. However, the percentages of IFN-γ, IL-10 and IL-12 positive cells were decreased among infiltrating MNC of cauda equine in IL-18-/- mice. This indicates that IL-18 deficiency inhibits the production of both Th1 and Th2 cytokines in the target organ of mice with EAN.

KW - EAN

KW - IL-18

KW - Th1 cytokines

KW - Th2 cytokines

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IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis

Abstract

Keywords

ASJC Scopus subject areas

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