Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

Farheen Badrealam Khan, Shahab Uddin, Abozer Y. Elderdery, Khang Wen Goh, Long Chiau Ming, Chrismawan Ardianto, Abdul Rasheed Palakot, Irfa Anwar, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Jayasimha Rayalu Daddam, Meraj Alam Khan, Shoaib Shoaib, Md Khursheed, Sara Reshadat, Hamid Reza Khayat Kashani, Sameer Mirza, Abbas A. Khaleel, Mohammed Akli Ayoub

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.

Original languageEnglish
Article number3664
JournalCells
Volume11
Issue number22
DOIs
Publication statusPublished - Nov 2022

Keywords

  • cardiovascular disease
  • circRNA
  • exosomes
  • lncRNA
  • miRNA
  • ncRNA

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential'. Together they form a unique fingerprint.

Cite this