Immobilization of enzymes in porous solids under restricted diffusion conditions

Md M. Hossain, D. D. Do, J. E. Bailey

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


A restricted diffusion model is developed to study the immobilization of enzyme in porous solid supports. Simulation studies have been carried out for various combinations of process variables and parameters of the immobilization system. The model has also been used to develop a method for estimating the intrinsic rate constant of immobilization when enzyme diffusion into the support is restricted. Results of experiments in which glucose oxidase was immobilized in porous glass supports are consistent with model simulations.

Original languageEnglish
Pages (from-to)1088-1098
Number of pages11
JournalAIChE Journal
Issue number7
Publication statusPublished - Jul 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • General Chemical Engineering


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