Immunity as a link between obesity and insulin resistance

Nishan S. Kalupahana, Naima Moustaid-Moussa, Kate J. Claycombe

Research output: Contribution to journalArticlepeer-review

203 Citations (Scopus)

Abstract

Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review.

Original languageEnglish
Pages (from-to)26-34
Number of pages9
JournalMolecular Aspects of Medicine
Volume33
Issue number1
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

Keywords

  • Adipose tissue inflammation
  • Insulin resistance
  • Obesity
  • Type-2 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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