Immunophenotype of hairy‐cell leukemia

I. B. Hassan; H. Hagberg; C. Sundström

doi:10.1111/j.1600-0609.1990.tb00447.x

Immunophenotype of hairy‐cell leukemia

I. B. Hassan, H. Hagberg, C. Sundström

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10^‐, CD19+, CD20+, CD21^‐, CD22+, CD37+, CD38^‐, FMC7+, LN1+, PCA‐1+, BLy7+and CD5^‐). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.

Original language	English
Pages (from-to)	172-176
Number of pages	5
Journal	European Journal of Haematology
Volume	45
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0609.1990.tb00447.x
Publication status	Published - Sept 1990
Externally published	Yes

Keywords

BLy7
hairy cell leukemia
immunophenotype
monoclonal antibodies

ASJC Scopus subject areas

Hematology

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10.1111/j.1600-0609.1990.tb00447.x

Cite this

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title = "Immunophenotype of hairy‐cell leukemia",

abstract = "15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10‐, CD19+, CD20+, CD21‐, CD22+, CD37+, CD38‐, FMC7+, LN1+, PCA‐1+, BLy7+and CD5‐). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.",

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language = "English",

volume = "45",

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TY - JOUR

T1 - Immunophenotype of hairy‐cell leukemia

AU - Hassan, I. B.

AU - Hagberg, H.

AU - Sundström, C.

PY - 1990/9

Y1 - 1990/9

N2 - 15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10‐, CD19+, CD20+, CD21‐, CD22+, CD37+, CD38‐, FMC7+, LN1+, PCA‐1+, BLy7+and CD5‐). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.

AB - 15 cases of HCL were studied with a panel of monoclonal antibodies against different leukocyte antigens. A B‐cell phenotype different from that of B‐CLL was observed (CD10‐, CD19+, CD20+, CD21‐, CD22+, CD37+, CD38‐, FMC7+, LN1+, PCA‐1+, BLy7+and CD5‐). As expected, CD11c and CD25 were positive and, in addition, a My7 and My9 positivity in varying degree was noted. 3 weeks of in vitro incubation did not significantly alter the phenotype. We conclude that HCL exhibits a unique phenotype among chronic B‐cell leukemias, which is closer to the plasma cell stage of differentiation than that of B‐CLL. The BLy7 monoclonal antibody seems to be a promising marker for HCL.

KW - BLy7

KW - hairy cell leukemia

KW - immunophenotype

KW - monoclonal antibodies

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Immunophenotype of hairy‐cell leukemia

Abstract

Keywords

ASJC Scopus subject areas

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