Immunotherapy for Alzheimer’s Disease: Current Scenario and Future Perspectives

M. B. Usman, S. Bhardwaj, S. Roychoudhury, D. Kumar, A. Alexiou, P. Kumar, R. K. Ambasta, P. Prasher, S. Shukla, V. Upadhye, F. A. Khan, R. Awasthi, M. D. Shastri, S. K. Singh, G. Gupta, D. K. Chellappan, K. Dua, S. K. Jha, J. Ruokolainen, K. K. KesariShreesh Ojha, Niraj Kumar Jha

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) is a global health concern owing to its complexity, which often poses a great challenge to the development of therapeutic approaches. No single theory has yet accounted for the various risk factors leading to the pathological and clinical manifestations of dementiatype AD. Therefore, treatment options targeting various molecules involved in the pathogenesis of the disease have been unsuccessful. However, the exploration of various immunotherapeutic avenues revitalizes hope after decades of disappointment. The hallmark of a good immunotherapeutic candidate is not only to remove amyloid plaques but also to slow cognitive decline. In line with this, both active and passive immunotherapy have shown success and limitations. Recent approval of aducanumab for the treatment of AD demonstrates how close passive immunotherapy is to being successful. However, several major bottlenecks still need to be resolved. This review outlines recent successes and challenges in the pursuit of an AD vaccine.

Original languageEnglish
Pages (from-to)534-551
Number of pages18
JournalThe journal of prevention of Alzheimer's disease
Volume8
Issue number4
DOIs
Publication statusPublished - Sept 2021

Keywords

  • Alzheimer’s disease
  • active immunotherapy
  • amyloid plaque
  • monoclonal antibody
  • passive immunotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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