TY - JOUR
T1 - Impact of Digoxin on Mortality in Patients with Atrial Fibrillation Stratified by Heart Failure
T2 - Findings from Gulf Survey of Atrial Fibrillation Events in the Middle East
AU - Al-Zakwani, Ibrahim
AU - Panduranga, P.
AU - Zubaid, M.
AU - Sulaiman, K.
AU - Rashed, W. A.
AU - Alsheikh-Ali, A. A.
AU - Almahmeed, W.
AU - Shehab, A.
AU - Al Qudaimi, A.
AU - Asaad, N.
AU - Amin, H.
N1 - Publisher Copyright:
© SAGE Publications.
PY - 2016/5
Y1 - 2016/5
N2 - Objective: The use of digoxin in patients having atrial fibrillation (AF) with or without heart failure (HF) is not without controversy. The aim of this study was to examine the impact of digoxin therapy on mortality stratified by HF. Methods: Gulf Survey of Atrial Fibrillation Events was a prospective, multinational, observational registry of consecutive patients with AF recruited from the emergency department of 23 hospitals in 6 countries in the Middle East. Patients were recruited between October 2009 and June 2010 and followed up for 1 year after enrollment. Analyses were performed using univariate and multivariate statistical techniques. Results: The study included a total of 1962 patients with AF, with an overall mean age of 56 ± 16 years, and 52% (n = 1026) were males. At hospital discharge, digoxin was prescribed in 36% (n = 709) of the patients, whereas HF was present in 27% (n = 528) of the cohort. A total of 225 (12.1%) patients died during the 12-month follow-up period after discharge (5.3% [n = 104] were lost to follow-up). Patients with HF were consistently associated with higher mortality at 1 month (5.1% vs 2.1%; P <.001), 6 months (17.2% vs 5.0%; P < 0.001), and 12 months (24.3% vs 7.6%; P <.001) when compared to those without HF. When stratified by HF, digoxin therapy was associated with significantly higher mortality in those without HF at 6 months (8.7% vs 3.7%; adjusted odds ratio (aOR), 5.07; P <.001) and 12 months (12.3% vs 6.0%; aOR, 4.22; P <.001) but not in those with HF (6 months: 18.6% vs 14.7%; aOR, 1.62; P =.177 and 12 months: 25.4% vs 22.4%; aOR, 1.37; P =.317). Conclusions: In patients with AF and HF, digoxin did not offer any survival advantages. However, in those without HF, digoxin therapy was, in fact, associated with significantly higher long-term mortality.
AB - Objective: The use of digoxin in patients having atrial fibrillation (AF) with or without heart failure (HF) is not without controversy. The aim of this study was to examine the impact of digoxin therapy on mortality stratified by HF. Methods: Gulf Survey of Atrial Fibrillation Events was a prospective, multinational, observational registry of consecutive patients with AF recruited from the emergency department of 23 hospitals in 6 countries in the Middle East. Patients were recruited between October 2009 and June 2010 and followed up for 1 year after enrollment. Analyses were performed using univariate and multivariate statistical techniques. Results: The study included a total of 1962 patients with AF, with an overall mean age of 56 ± 16 years, and 52% (n = 1026) were males. At hospital discharge, digoxin was prescribed in 36% (n = 709) of the patients, whereas HF was present in 27% (n = 528) of the cohort. A total of 225 (12.1%) patients died during the 12-month follow-up period after discharge (5.3% [n = 104] were lost to follow-up). Patients with HF were consistently associated with higher mortality at 1 month (5.1% vs 2.1%; P <.001), 6 months (17.2% vs 5.0%; P < 0.001), and 12 months (24.3% vs 7.6%; P <.001) when compared to those without HF. When stratified by HF, digoxin therapy was associated with significantly higher mortality in those without HF at 6 months (8.7% vs 3.7%; adjusted odds ratio (aOR), 5.07; P <.001) and 12 months (12.3% vs 6.0%; aOR, 4.22; P <.001) but not in those with HF (6 months: 18.6% vs 14.7%; aOR, 1.62; P =.177 and 12 months: 25.4% vs 22.4%; aOR, 1.37; P =.317). Conclusions: In patients with AF and HF, digoxin did not offer any survival advantages. However, in those without HF, digoxin therapy was, in fact, associated with significantly higher long-term mortality.
KW - atrial fibrillation
KW - digoxin
KW - heart failure
KW - middle east
KW - mortality
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U2 - 10.1177/1074248415603505
DO - 10.1177/1074248415603505
M3 - Article
C2 - 26341119
AN - SCOPUS:84963665525
SN - 1074-2484
VL - 21
SP - 273
EP - 279
JO - Journal of Cardiovascular Pharmacology and Therapeutics
JF - Journal of Cardiovascular Pharmacology and Therapeutics
IS - 3
ER -