TY - JOUR
T1 - Impact of early use of long-acting injectable antipsychotics on functional outcome in first episode psychosis
T2 - a 3-year longitudinal study
AU - Abdel-Baki, Amal
AU - Poulin, Émile
AU - Medrano, Sofia
AU - Pires de Oliveira Padilha, Paula
AU - Stip, Emmanuel
AU - Potvin, Stéphane
N1 - Funding Information:
AAB received research funds from Fonds de Recherche en Santé du Québec (FRQS) and the Canadian Institutes of Health Research (CIHR). More than 3 years ago, AAB received speaker fees and research grants from Janssen-Ortho, and has also received research funds for a master's student grant from Otsuka-Lundbeck and has been part of one of its advisory committees. SP is the holder of a grant from Otsuka Pharmaceuticals. ES received funding from Fond de Recherche du Québec en Santé—Partenariat JANSSEN 2020, University of Arab Emirates, and CMHS 2020. The other authors declare no conflict of interest.
Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Objectives: To describe, in a naturalistic setting, the impact of the early use of LAI-AP on functional outcomes of early psychosis patients as compared to oral antipsychotics (OAP). Methods: Longitudinal prospective 3-year naturalistic study of all consecutive admissions (n = 416) to two Early intervention services (EIS) for psychosis comparing baseline characteristics and the evolution of global functioning, occupation (work and studies), and living arrangements autonomy according to the route of administration of the antipsychotic medication. The cohort was divided into four groups: LAI-AP first (started on LAI-AP and later received OAP), OAP first, LAI-AP only, and OAP only. Results: Global assessment of functioning (GAF) improved in all groups, but our mixed-effect model did not show any significant association between the route of administration and the GAF outcome. The LAI-AP only group was significantly less likely to have extreme residential instability at 3 years than the other groups despite its highest proportion of homeless youth and their poor prognostic factors at baseline. Conclusions: Our naturalistic study suggests a significant protective effect of LAI-AP on extreme residential instability for the most vulnerable patients, but no impact of the first AP administration route on other functional outcomes was observed at 3 years of follow-up. Key points Long-acting injectable antipsychotics seem promising to avoid extreme residential instability in early psychosis. Global assessment of functioning (GAF) improved in all groups. There was no significant association between the first route of administration and global functionning.
AB - Objectives: To describe, in a naturalistic setting, the impact of the early use of LAI-AP on functional outcomes of early psychosis patients as compared to oral antipsychotics (OAP). Methods: Longitudinal prospective 3-year naturalistic study of all consecutive admissions (n = 416) to two Early intervention services (EIS) for psychosis comparing baseline characteristics and the evolution of global functioning, occupation (work and studies), and living arrangements autonomy according to the route of administration of the antipsychotic medication. The cohort was divided into four groups: LAI-AP first (started on LAI-AP and later received OAP), OAP first, LAI-AP only, and OAP only. Results: Global assessment of functioning (GAF) improved in all groups, but our mixed-effect model did not show any significant association between the route of administration and the GAF outcome. The LAI-AP only group was significantly less likely to have extreme residential instability at 3 years than the other groups despite its highest proportion of homeless youth and their poor prognostic factors at baseline. Conclusions: Our naturalistic study suggests a significant protective effect of LAI-AP on extreme residential instability for the most vulnerable patients, but no impact of the first AP administration route on other functional outcomes was observed at 3 years of follow-up. Key points Long-acting injectable antipsychotics seem promising to avoid extreme residential instability in early psychosis. Global assessment of functioning (GAF) improved in all groups. There was no significant association between the first route of administration and global functionning.
KW - employment
KW - first-episode psychosis
KW - functional outcome
KW - homelessness
KW - long-acting injectable antipsychotic
KW - Schizophrenia
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U2 - 10.1080/13651501.2022.2079531
DO - 10.1080/13651501.2022.2079531
M3 - Article
C2 - 35654421
AN - SCOPUS:85131517065
SN - 1365-1501
JO - International Journal of Psychiatry in Clinical Practice
JF - International Journal of Psychiatry in Clinical Practice
ER -