Impact of helicobacter pylori-related metabolic syndrome parameters on arterial hypertension

Jannis Kountouras, Apostolis Papaefthymiou, Stergios A. Polyzos, Georgia Deretzi, Elisabeth Vardaka, Elpidoforos S. Soteriades, Maria Tzitiridou-Chatzopoulou, Paraskevas Gkolfakis, Kyriaki Karafyllidou, Michael Doulberis

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Arterial hypertension is a risk factor for several pathologies, mainly including cardio-cerebrovascular diseases, which rank as leading causes of morbidity and mortality worldwide. Arterial hypertension also constitutes a fundamental component of the metabolic syndrome. Helicobacter pylori infection is one of the most common types of chronic infection globally and displays a plethora of both gastric and extragastric effects. Among other entities, Helicobacter pylori has been implicated in the pathogenesis of the metabolic syndrome. Within this review, we illustrate the current state-of-the-art evidence, which may link several components of the Helicobacter pylori-related metabolic syndrome, including non-alcoholic fatty liver disease and arterial hypertension. In particular, current knowledge of how Helicobacter pylori exerts its virulence through dietary, inflammatory and metabolic pathways will be discussed. Although there is still no causative link between these entities, the emerging evidence from both basic and clinical research supports the proposal that several components of the Helicobacter pylori infection-related metabolic syndrome present an important risk factor in the development of arterial hypertension. The triad of Helicobacter pylori infection, the metabolic syndrome, and hypertension represents a crucial worldwide health problem on a pandemic scale with high morbidity and mortality, like COVID-19, thereby requiring awareness and appropriate management on a global scale.

Original languageEnglish
Article number2351
Issue number11
Publication statusPublished - Nov 2021
Externally publishedYes


  • Arterial hypertension
  • Atherosclerosis
  • Diet
  • Helicobacter pylori
  • Inflammation
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology


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