Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea

T. E. Adrian, H. S. Besterman, C. N. Mallinson, C. Garalotis, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Pancreatic polypeptide (PP) is a newly discovered hormonal peptide localized in a distinct endocrine cell type in the pancreas. PP circulates in plasma and in normal subjects levels rise substantially on the ingestion of food (mean rise 138 pmol/l). In 10 patients with chronic pancreatitis with exocrine deficiency, the PP response to a test breakfast was greatly reduced (mean rise 20 pmol/l, p < 0.001). PP response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalUnknown Journal
Issue number2
Publication statusPublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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