In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

Ahmed M. Mansour; Rabaa M. Khaled; Krzysztof Radacki; Zeina Younes; Mariam Gamal; Beatrice Guirguis; Gamal A.E. Mostafa; Essam A. Ali; Ola R. Shehab

doi:10.1039/d3dt01798b

In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

Ahmed M. Mansour
, Rabaa M. Khaled
, Krzysztof Radacki
, Zeina Younes
, Mariam Gamal
, Beatrice Guirguis
, Gamal A.E. Mostafa
, Essam A. Ali
, Ola R. Shehab

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC₅₀ = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

Original language	English
Pages (from-to)	10286-10293
Number of pages	8
Journal	Dalton Transactions
Volume	52
Issue number	30
DOIs	https://doi.org/10.1039/d3dt01798b
Publication status	Published - Jul 19 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Inorganic Chemistry

Access to Document

10.1039/d3dt01798b

Cite this

@article{7854bb01fe86404d95cf5847f5f5c1eb,

title = "In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia",

abstract = "Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.",

author = "Mansour, \{Ahmed M.\} and Khaled, \{Rabaa M.\} and Krzysztof Radacki and Zeina Younes and Mariam Gamal and Beatrice Guirguis and Mostafa, \{Gamal A.E.\} and Ali, \{Essam A.\} and Shehab, \{Ola R.\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = jul,

day = "19",

doi = "10.1039/d3dt01798b",

language = "English",

volume = "52",

pages = "10286--10293",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "30",

}

TY - JOUR

T1 - In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

AU - Mansour, Ahmed M.

AU - Khaled, Rabaa M.

AU - Radacki, Krzysztof

AU - Younes, Zeina

AU - Gamal, Mariam

AU - Guirguis, Beatrice

AU - Mostafa, Gamal A.E.

AU - Ali, Essam A.

AU - Shehab, Ola R.

PY - 2023/7/19

Y1 - 2023/7/19

N2 - Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

AB - Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 ± 0.8 μM) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 ± 4.1 μM) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

UR - https://www.scopus.com/pages/publications/85166264049

UR - https://www.scopus.com/pages/publications/85166264049#tab=citedBy

U2 - 10.1039/d3dt01798b

DO - 10.1039/d3dt01798b

M3 - Article

C2 - 37466155

AN - SCOPUS:85166264049

SN - 1477-9226

VL - 52

SP - 10286

EP - 10293

JO - Dalton Transactions

JF - Dalton Transactions

IS - 30

ER -

In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

Abstract

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this