TY - JOUR
T1 - In vitro investigation of bioactivities of solid-state fermented lupin, quinoa and wheat using Lactobacillus spp.
AU - Ayyash, Mutamed
AU - Johnson, Stuart K.
AU - Liu, Shao Quan
AU - Mesmari, Nouf
AU - Dahmani, Shaikhah
AU - Al Dhaheri, Ayesha S.
AU - Kizhakkayil, Jaleel
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/3/1
Y1 - 2019/3/1
N2 - This study is an in-vitro investigation of the health-promoting properties of fermented whole-grain lupin, quinoa and wheat, using 72 h solid-state fermentation by Lactobacillus reuteri K777 and Lb. plantarum K779. Antiproliferative activity against Caco-2 and MCF-7 cancer cell lines (tumour cell lines of intestinal and mammary origin, respectively) was investigated, as well as α-amylase and α-glucosidase inhibition, antihypertensive, antioxidant and proteolytic activities. ABTS antioxidant activities of fermented lupin (FL, 55% w/v), quinoa (FQ, 55% w/v) and wheat (FW, 55% w/v) ranged from ∼12.0% to 55.0%, ∼17.6% to 73.0%, and ∼29.0% to 26.0%, respectively. Lupin, quinoa and wheat fermented by L. plantarum had pronounced antihypertensive activities (∼85%). The α-glucosidase inhibition in FL was higher than that of FQ and FW. The magnitude of the antiproliferative activities of FL was markedly greater (p < 0.05) than of FQ and FW by approximately three-fold and two-folds against Caco-2 and MCF-7 cell lines, respectively.
AB - This study is an in-vitro investigation of the health-promoting properties of fermented whole-grain lupin, quinoa and wheat, using 72 h solid-state fermentation by Lactobacillus reuteri K777 and Lb. plantarum K779. Antiproliferative activity against Caco-2 and MCF-7 cancer cell lines (tumour cell lines of intestinal and mammary origin, respectively) was investigated, as well as α-amylase and α-glucosidase inhibition, antihypertensive, antioxidant and proteolytic activities. ABTS antioxidant activities of fermented lupin (FL, 55% w/v), quinoa (FQ, 55% w/v) and wheat (FW, 55% w/v) ranged from ∼12.0% to 55.0%, ∼17.6% to 73.0%, and ∼29.0% to 26.0%, respectively. Lupin, quinoa and wheat fermented by L. plantarum had pronounced antihypertensive activities (∼85%). The α-glucosidase inhibition in FL was higher than that of FQ and FW. The magnitude of the antiproliferative activities of FL was markedly greater (p < 0.05) than of FQ and FW by approximately three-fold and two-folds against Caco-2 and MCF-7 cell lines, respectively.
KW - 1,1-Diphenyl-2-picrylhydrazyl DPPH (PubChem CID: 2735032)
KW - Anticancer
KW - Antihypertensive
KW - Cereal
KW - Fermentation
KW - Hippuryl-histidyl-leucine (PubChem CID: 94418)
KW - Probiotic
KW - o-Phthalaldehyde (PubChem CID: 4807)
KW - p-Nitrophenyl α-D-glucopyranoside (PubChem CID: 102764)
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U2 - 10.1016/j.foodchem.2018.09.031
DO - 10.1016/j.foodchem.2018.09.031
M3 - Article
C2 - 30724226
AN - SCOPUS:85053785386
SN - 0308-8146
VL - 275
SP - 50
EP - 58
JO - Food Chemistry
JF - Food Chemistry
ER -