In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

R. J. Moore; B. Issa; P. Tokarczuk; K. R. Duncan; P. Boulby; P. N. Baker; R. W. Bowtell; B. S. Worthington; I. R. Johnson; P. A. Gowland

doi:10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

R. J. Moore, B. Issa, P. Tokarczuk, K. R. Duncan, P. Boulby, P. N. Baker, R. W. Bowtell, B. S. Worthington, I. R. Johnson, P. A. Gowland

Department of Physics

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10^-3 mm²/sec, and D* was 57 ± 41 x 10^-3 mm²/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	295-302
Number of pages	8
Journal	Magnetic Resonance in Medicine
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2
Publication status	Published - 2000

Keywords

EPI
Human placenta
IVIM
Optimization
PGSE

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

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Moore, R. J., Issa, B., Tokarczuk, P., Duncan, K. R., Boulby, P., Baker, P. N., Bowtell, R. W., Worthington, B. S., Johnson, I. R., & Gowland, P. A. (2000). In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T. Magnetic Resonance in Medicine, 43(2), 295-302. https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

Moore, RJ, Issa, B, Tokarczuk, P, Duncan, KR, Boulby, P, Baker, PN, Bowtell, RW, Worthington, BS, Johnson, IR & Gowland, PA 2000, 'In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T', Magnetic Resonance in Medicine, vol. 43, no. 2, pp. 295-302. https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

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abstract = "This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10-3 mm2/sec, and D* was 57 ± 41 x 10-3 mm2/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.",

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In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

Abstract

Keywords

ASJC Scopus subject areas

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