In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

R. J. Moore; B. Issa; P. Tokarczuk; K. R. Duncan; P. Boulby; P. N. Baker; R. W. Bowtell; B. S. Worthington; I. R. Johnson; P. A. Gowland

doi:10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

R. J. Moore, B. Issa, P. Tokarczuk, K. R. Duncan, P. Boulby, P. N. Baker, R. W. Bowtell, B. S. Worthington, I. R. Johnson, P. A. Gowland

Department of Physics

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10^-3 mm²/sec, and D* was 57 ± 41 x 10^-3 mm²/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	295-302
Number of pages	8
Journal	Magnetic Resonance in Medicine
Volume	43
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2
Publication status	Published - 2000

Keywords

EPI
Human placenta
IVIM
Optimization
PGSE

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

Cite this

Moore, R. J., Issa, B., Tokarczuk, P., Duncan, K. R., Boulby, P., Baker, P. N., Bowtell, R. W., Worthington, B. S., Johnson, I. R., & Gowland, P. A. (2000). In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T. Magnetic Resonance in Medicine, 43(2), 295-302. https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

Moore, RJ, Issa, B, Tokarczuk, P, Duncan, KR, Boulby, P, Baker, PN, Bowtell, RW, Worthington, BS, Johnson, IR & Gowland, PA 2000, 'In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T', Magnetic Resonance in Medicine, vol. 43, no. 2, pp. 295-302. https://doi.org/10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

@article{8d33538afc2e4a9db2995c9d0e9f07ee,

title = "In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T",

abstract = "This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10-3 mm2/sec, and D* was 57 ± 41 x 10-3 mm2/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.",

keywords = "EPI, Human placenta, IVIM, Optimization, PGSE",

author = "Moore, {R. J.} and B. Issa and P. Tokarczuk and Duncan, {K. R.} and P. Boulby and Baker, {P. N.} and Bowtell, {R. W.} and Worthington, {B. S.} and Johnson, {I. R.} and Gowland, {P. A.}",

year = "2000",

doi = "10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2",

language = "English",

volume = "43",

pages = "295--302",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

AU - Moore, R. J.

AU - Issa, B.

AU - Tokarczuk, P.

AU - Duncan, K. R.

AU - Boulby, P.

AU - Baker, P. N.

AU - Bowtell, R. W.

AU - Worthington, B. S.

AU - Johnson, I. R.

AU - Gowland, P. A.

PY - 2000

Y1 - 2000

N2 - This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10-3 mm2/sec, and D* was 57 ± 41 x 10-3 mm2/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.

AB - This paper presents the first in vivo measurements of intravoxel incoherent motion in the human placenta, obtained using the pulsed gradient spin echo (PGSE) sequence. The aims of this study were two-fold. The first was to provide an initial estimate of the values of the IVIM parameters in this organ, which are currently unknown. The second aim was then to use these results to optimize the sequence timings for future studies. The moving blood fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*) were measured. The average value of f was 26 ± 6 % (mean ± SD), D was 1.7 ± 0.5 x 10-3 mm2/sec, and D* was 57 ± 41 x 10-3 mm2/sec. For the optimized values of b, the expected percentage uncertainty in the fitted values of f, D, and D* for the placenta were σf/f = 14.9%, σD/D = 14.3%, σD*/D* = 44.9%, for an image signal-to-noise of 20:1, and a total imaging time of 800 sec. (C) 2000 Wiley-Liss, Inc.

KW - EPI

KW - Human placenta

KW - IVIM

KW - Optimization

KW - PGSE

UR - http://www.scopus.com/inward/record.url?scp=0033979361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033979361&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

DO - 10.1002/(SICI)1522-2594(200002)43:2<295::AID-MRM18>3.0.CO;2-2

M3 - Article

C2 - 10680695

AN - SCOPUS:0033979361

SN - 0740-3194

VL - 43

SP - 295

EP - 302

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -

In vivo intravoxel incoherent motion measurements in the human placenta using echo-planar imaging at 0.5 T

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this