In vivo protective effects of nootkatone against particles-induced lung injury caused by diesel exhaust is mediated via the Nf-κB pathway

Medicine & Life Sciences

• nootkatone 100%
• Vehicle Emissions 68%
• Lung Injury 51%
• Lung 13%
• Airway Resistance 12%
• Air Pollution 11%
• Neutrophil Infiltration 11%
• NF-kappa B 10%
• DNA Damage 8%
• Pneumonia 7%
• Citrus paradisi 7%
• Oxidative Stress 7%
• 8-epi-prostaglandin F2alpha 6%
• Protective Agents 6%
• Bronchoalveolar Lavage Fluid 5%
• Glutathione 4%
• Caspase 3 4%
• Nitric Oxide 3%
• Antioxidants 3%
• Anti-Inflammatory Agents 3%
• Tumor Necrosis Factor-alpha 3%
• Macrophages 3%
• Apoptosis 2%

Agriculture & Biology

• nootkatone 82%
• protective effect 46%
• lungs 38%
• transcription factor NF-kappa B 14%
• air pollution 11%
• DNA damage 9%
• neutrophils 9%
• inflammation 8%
• mice 8%
• adverse effects 7%
• oxidative stress 7%
• pretreatment 7%
• toxicity 6%
• tumor necrosis factors 6%
• lung function 6%
• grapefruits 6%
• caspase-3 6%
• endpoints 5%
• anti-inflammatory activity 5%
• particulates 4%
• apoptosis 4%
• macrophages 4%
• nitric oxide 4%
• cleavage (chemistry) 4%
• glutathione 4%
• fluids 3%
• antioxidants 3%