Inactivation of Pink1 gene in Vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

M. Emdadul Haque, Matthew P. Mount, Farzaneh Safarpour, Elizabeth Abdel-Messih, Steve Callaghan, Chantal Mazerolle, Tohru Kitada, Ruth S. Slack, Valerie Wallace, Jie Shen, Hymie Anisman, David S. Park

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Neuroscience

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Biochemistry, Genetics and Molecular Biology