Increased glomerular albumin permeability in old spontaneously hypertensive rats

Omran Bakoush, Jan Tencer, Ole Torffvit, Olav Tenstad, Ingela Skogvall, Bengt Rippe

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background. Severe long-standing hypertension is associated with an increased urinary protein excretion. Methods. To investigate the mechanisms of this proteinuria, we measured the glomerular clearances and calculated the glomerular sieving coefficients (θ) for neutral albumin (θo-alb) and for native albumin (θalb) in spontaneously hypertensive rats (SHR) at the ages of 3, 9 and 14 months, in comparison with age-matched normal control Wistar rats (NCR). The hypothesis was that increases in the glomerular permeability of both negatively charged and neutral albumin would indicate a preferential size-selective dysfunction of the glomerular capillary wall (GCW), while an increased permeability to negatively charged albumin, as compared with neutral albumin, predominantly would indicate a charge-selectivity dysfunction of the GCW. A tissue (renal) uptake technique together with urinary sampling was used to assess θ. The glomerular filtration rate was assessed using the plasma to urine clearance of 51Cr-EDTA. Results. The θalb in SHR increased 2.6 times at 14 months of age as compared with at 3 months, while there was no significant change of θalb in NCR with age. Furthermore, the increased θalb in old SHR correlated significantly with an increase in θo-alb (r=0.86, P< 0.001), suggesting that albuminuria in old SHR primarily results from an increased number of rather unselective ('large') pores in the glomerular filter. Conclusions. In old age, but not at a young age, hypertensive rats develop proteinuria as a result of dysfunction of the glomerular capillary filter, affecting primarily its size-selectivity. The changes are functionally compatible with the appearance in the glomerular barrier of an increased number of more unselective pores.

Original languageEnglish
Pages (from-to)1724-1731
Number of pages8
JournalNephrology Dialysis Transplantation
Issue number7
Publication statusPublished - Jun 2004
Externally publishedYes


  • Albuminuria
  • Charge-selectivity
  • Glomerular capillary wall
  • Hypertension
  • Macmolecular transport

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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